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首页> 外文期刊>Journal of glaucoma >Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma.
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Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma.

机译：玻璃体腔内贝伐单抗联合小梁切除联合丝裂霉素C与小梁切除联合丝裂霉素C联合治疗新生血管性青光眼。

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PURPOSE: To evaluate the effects of intravitreal bevacizumab (IVB) before mitomycin C trabeculectomy (MMCT) for neovascular glaucoma (NVG). METHODS: The study is a retrospective, comparative, consecutive case series. The study group consisted of 57 eyes from 50 patients with NVG who underwent a first MMCT: 33 eyes were treated with MMCT alone between June 1, 2005 and May 17, 2007 (Control Group); and, 24 eyes were treated with a combination of IVB and MMCT after May 18, 2007 (IVB Group). Surgical complications, intraocular pressure (IOP), and the probability of success were compared between the 2 groups. Surgical failure was defined as IOP >/=22 mm Hg for 2 consecutive follow-up visits, a deterioration of visual acuity to no light perception, or additional glaucoma surgeries. RESULTS: There were no significant differences in preoperative data between the groups. Hyphema associated with MMCT occurred significantly less often in the IVB Group (P=0.006). IOPs at 7 and 10 days after MMCT were significantly lower in the IVB Group (P=0.01 and 0.02, respectively). However, Kaplan-Meier survival-curve analysis showed the probability of success 120, 240, and 360 days after MMCT of 87.5%, 79.2%, and 65.2% in the IVB Group, and 75.0%, 71.9%, and 65.3% in the Control Group. No significant difference in survival times was found between the groups (P=0.76). CONCLUSIONS: IVB before MMCT reduced hyphema associated with MMCT for NVG. IVB provided further IOP reduction immediately after MMCT, but did not significantly improve surgical outcomes over longer periods.
机译：目的：评估丝裂霉素C小梁切除术（MMCT）之前玻璃体内贝伐单抗（IVB）对新生血管性青光眼（NVG）的作用。方法：该研究是回顾性，比较性，连续性病例系列。该研究组由来自50例行初次MMCT的NVG患者的57眼组成：在2005年6月1日至2007年5月17日期间，仅对33眼进行了MMCT治疗（对照组）。 2007年5月18日之后，IVB和MMCT联合治疗24眼（IVB组）。比较两组的手术并发症，眼压（IOP）和成功率。手术失败定义为连续2次随访，眼压下降至无光感知或进行其他青光眼手术的IOP> / = 22 mm Hg。结果：两组之间的术前数据无显着差异。 IVB组中与MMCT相关的前房积血发生率显着降低（P = 0.006）。 IVB组在MMCT后7天和10天的IOP显着降低（分别为P = 0.01和0.02）。但是，Kaplan-Meier生存曲线分析显示，MMCT组成功进行MMCT后120、240和360天的概率分别为87.5％，79.2％和65.2％，IVB组为75.0％，71.9％和65.3％。控制组。两组之间的生存时间无显着差异（P = 0.76）。结论：MMCT前的IVB减少了NVG与MMCT相关的前房积血。 MMCT后，IVB可进一步降低IOP，但长期而言，并不能显着改善手术效果。

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