Zebrafish as a model to study drug transporters at the bloodbrain barrier

UmansR.A.; TaylorM.R.

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Zebrafish as a model to study drug transporters at the bloodbrain barrier

机译：斑马鱼作为研究血脑屏障药物转运蛋白的模型

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The blood-brain barrier (BBB) restricts the delivery of therapeutics into the central nervous system (CNS). This limitation is due largely to localization of drug transport mechanisms to the brain endothelial cells (BECs). Although mammalian and in vitro models are currently used to study drug transport, zebrafish (Danio rerio) are advantageous for dissecting complex biological problems such as the BBB. This report focuses on zebrafish as a suitable model system for studying the BBB and drug transport.

机译：血脑屏障（BBB）限制了治疗剂向中枢神经系统（CNS）的输送。该限制主要是由于药物转运机制定位于脑内皮细胞（BEC）。尽管目前使用哺乳动物和体外模型研究药物运输，但斑马鱼（Danio rerio）对于剖析诸如BBB之类的复杂生物学问题是有利的。本报告重点介绍斑马鱼作为研究血脑屏障和药物运输的合适模型系统。

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《Clinical Pharmacology and Therapeutics》 |2012年第5期|共4页
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UmansR.A.; TaylorM.R.;
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正文语种 eng
中图分类药理学;
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1. Zebrafish as a model to study drug transporters at the bloodbrain barrier [J] . UmansR.A., TaylorM.R. Clinical Pharmacology and Therapeutics . 2012,第5期

机译：斑马鱼作为研究血脑屏障药物转运蛋白的模型
2. Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers [J] . Li Ye, Miao Xiaoqing, Chen Tongkai, Colloids and Surfaces, B. Biointerfaces . 2017,第期

机译：Zebrafish作为一种视觉和动态模型，用于研究跨越生物屏障的纳米药物递送系统的运输
3. The expected characteristics of an in vitro human Blood Brain Barrier model derived from cell lines, for studying how ABC transporters influence drug permeability [J] . Puech Clementine, Delavenne Xavier, Perek Nathalie Journal of drug delivery science and technology . 2018,第期

机译：衍生自细胞系的体外人体血脑屏障模型的预期特征，用于研究ABC转运蛋白如何影响药物渗透性的研究
4. Effect of Centella asiatica to the Glucose Transporter 4 and Osteocalcin on the Rotenonee-Induced Zebrafish Larvae (Danio rerio) Stunting Model [C] . Vanda Primaditya, Fitra Arsy Nur Coryah, Linda Ika Puspita Ariati, International Conference on Life Sciences and Technology . 2020

机译：Centella Asiatica对葡萄糖转运蛋白4和骨钙素对转子诱导的斑马鱼幼虫（Danio Rerio）静音模型的影响
5. Expression and function of drug transporters in an in vitro model of the mammary epithelial barrier (BME-UV). [D] . Al-bataineh, Mohammad M. 2010

机译：药物转运蛋白在乳腺上皮屏障（BME-UV）体外模型中的表达和功能。
6. Zebrafish as a Model to Study Drug Transporters at the Blood–Brain Barrier [O] . RA Umans, MR Taylor -1

机译：斑马鱼的血 - 脑屏障模型来研究药物转运
7. Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro BloodBrain Barrier Model [O] . -1

机译：在体外血脑屏障模型中小型和大分子药物运输研究的最小常旧性电阻阈值

Zebrafish as a model to study drug transporters at the bloodbrain barrier

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