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首页> 外文期刊>Journal of gastroenterology and hepatology >Age-related analysis of functional outcome and quality of life after restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis.
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Age-related analysis of functional outcome and quality of life after restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis.

机译:修复性结肠切除术和回肠袋肛门吻合术治疗家族性腺瘤性息肉病后的功能结局和生活质量的年龄相关分析。

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摘要

BACKGROUND: The aim of the present study was to evaluate the influence of a younger age at the time of ileal pouch-anal anastomosis (IPAA) on functional outcome and quality of life in patients with familial adenomatous polyposis (FAP). METHOD: A total of 105 patients with FAP who had undergone IPAA were retrieved from a dedicated Institutional Review Board (IRB)-approved IPAA database. Fifty-three patients who had complete follow-up data at 1, 3 and 5 years were included in the study. Patients were categorized into three groups according to their ages at the time of surgery. Group 1, patients < or =20 years of age (n = 9); group 2, patients >20 and < or = 40 years of age (n = 23); and group 3, patients >40 years of age (n = 21). Perioperative characteristics, postoperative complications, quality of life scores and functional outcome at 1, 3 and 5 years of postoperative follow-up were assessed. RESULTS: At any time point, there were no significant differences among the groups in terms of perioperative characteristics, quality of life scores or level of satisfaction with the procedure. However, younger patients had significantly lower nocturnal bowel movements at the first and third years of follow-up and tended to have less bowel movements per day at all stages of follow-up. CONCLUSION: These findings indicate that younger patients with FAP are inclined to have better functional outcome after IPAA in the early postoperative period. This finding may be encouraging for colorectal surgeons who will operate on young patients with FAP.
机译:背景:本研究的目的是评估回肠囊肛门吻合术(IPAA)时年龄较小对家族性腺瘤性息肉病(FAP)患者的功能结局和生活质量的影响。方法:从专门的机构审查委员会(IRB)批准的IPAA数据库中检索了总共105例行过IPAA的FAP患者。在研究中纳入了53名在1、3和5岁时具有完整随访数据的患者。根据患者在手术时的年龄将其分为三类。第1组,年龄小于或等于20岁的患者(n = 9);第2组,年龄大于20岁且小于或等于40岁的患者(n = 23);第三组,年龄> 40岁的患者(n = 21)。评估术后1,3,5年的围手术期特征,术后并发症,生活质量评分和功能结局。结果:在任何时候,两组的围手术期特征,生活质量得分或对手术的满意程度均无显着差异。但是,年轻的患者在随访的第一年和第三年夜间的排便明显较低,并且在随访的所有阶段中每天的排便趋势都较小。结论:这些发现表明,年轻的FAP患者在术后早期IPAA后倾向于有更好的功能预后。这一发现对于将要对年轻的FAP患者进行手术的结直肠外科医师来说可能是令人鼓舞的。

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