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首页> 外文期刊>Digestion >Relation of gallbladder motility to viscosity and composition of gallbladder bile in patients with cholesterol gallstones.
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Relation of gallbladder motility to viscosity and composition of gallbladder bile in patients with cholesterol gallstones.

机译：胆囊胆固醇结石患者胆囊动力与胆囊黏度和组成的关系。

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BACKGROUND/AIMS: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones. However, the relation of these parameters has not yet been determined. MATERIAL AND METHODS: Bile viscosity (mPa s) was measured by rotation viscosimetry and the composition of gallbladder bile was determined using standard methodology. Gallbladder motility was calculated as ejection fraction in percent of total volume 45 min after a test meal using ultrasonography in patients with gallstones prior to elective cholecystectomy. RESULTS: The study included 35 patients with cholesterol gallstones. Viscosity of gallbladder bile ranged between 0.9 and 12.5 mPa s (median 2.2 mPa s) and an ejection fraction of the gallbladder of 55.4 +/- 18.3% (mean +/- SD) was determined. No significant correlation (r = 0.19, p < 0.2) between the 2 parameters could be calculated. Analysis of the composition of gallbladder bile revealed a positive correlation of all components to biliary viscosity but not to the motility of the gallbladder, with the exceptions of a negative correlation (r = 0.39, p < 0.02) between mucin concentration and the ejection fraction at 45 min after the test meal. CONCLUSIONS: The motility of the gallbladder appears to be unrelated to the viscosity of gallbladder bile or gallbladder bile composition. The negative correlation between the ejection fraction of the gallbladder and mucin concentration of gallbladder bile suggests that chronic inflammation of the gallbladder wall is associated with both an impaired motility of the gallbladder and increased mucin release into gallbladder bile.
机译：背景/目的：胆囊胆汁中胆固醇的粘度增加和过饱和，以及胆囊运动性受损，被认为是胆固醇胆结石发病的重要因素。但是，这些参数之间的关系尚未确定。材料与方法：通过旋转粘度法测量胆汁粘度（mPa s），并使用标准方法测定胆囊胆汁的组成。对于胆囊结石患者，行选择性胆囊切除术前，使用超声检查，胆囊蠕动率计算为试验餐后45分钟的射血分数占总体积的百分比。结果：该研究包括35例胆固醇胆结石患者。胆囊胆汁的粘度在0.9至12.5mPa s（中值2.2mPa s）之间，并且胆囊的射血分数确定为55.4 +/- 18.3％（平均+/- SD）。不能计算出两个参数之间的显着相关性（r = 0.19，p <0.2）。对胆囊胆汁成分的分析显示，所有成分与胆汁粘度呈正相关，但与胆囊运动性无正相关，但粘蛋白浓度与射血分数之间呈负相关（r = 0.39，p <0.02）除外测试餐后45分钟。结论：胆囊的运动性似乎与胆囊胆汁或胆囊胆汁成分的粘度无关。胆囊射血分数与胆囊黏液粘蛋白浓度之间的负相关性提示胆囊壁的慢性炎症与胆囊运动性受损和粘蛋白向胆囊胆汁中释放的增加有关。

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