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首页> 外文期刊>Journal of hepato-biliary-pancreatic surgery >Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings.
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Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings.

机译:胆囊癌的癌前状况:组织病理学特征和分子遗传学发现的概述。

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摘要

Two distinct epithelial lesions (dysplasia and adenoma) and one high-risk condition (anomalous pancreatico-biliary ductal junction; APBDJ) are currently recognized as premalignant stages of gallbladder carcinogenesis. In addition to clinicopathologic observations, recent molecular genetic studies have provided further insight into the pathogenesis and biological behavior of these precursor lesions. In this review, we concentrate on describing the histopathologic and clinicopathologic background and recent molecular genetic findings for each of these putative precursor lesions.
机译:目前公认两种不同的上皮病变(不典型增生和腺瘤)和一种高危状况(胰胰腺胆管导管异常; APBDJ)是胆囊癌变的癌变前阶段。除了临床病理观察,最近的分子遗传学研究还提供了对这些前体病变的发病机制和生物学行为的进一步了解。在这篇综述中,我们集中于描述这些假定的前体病变的组织病理学和临床病理学背景以及最近的分子遗传学发现。

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