Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na(+)/H(+) exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

Zhang R; Lei L; Xu YG; Hua WY; Gong GQ

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Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na(+)/H(+) exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

机译：苯并咪唑-2-基或苯并咪唑-2-基硫代甲基苯甲酰胍作为新型Na（+）/ H（+）交换剂抑制剂，合成和针对缺血再灌注损伤的保护作用。

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A novel series of benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines were designed and synthesized as Na(+)/H(+)exchanger inhibitors. Most of them were found to inhibit NHE1-mediated platelet swelling in a concentration-dependent manner, and to have significant cardioprotective effect against myocardial ischemic-reperfusion injury, among which compounds 10a and 34 were more potent than cariporide in both in vivo and in vitro tests.

机译：设计并合成了一系列新型的苯并咪唑-2-基或苯并咪唑-2-基硫甲基苯甲酰胍作为Na（+）/ H（+）交换抑制剂。发现它们中的大多数以浓度依赖的方式抑制NHE1介导的血小板肿胀，并对心肌缺血再灌注损伤具有显着的心脏保护作用，其中化合物10a和34在体内和体外均比卡立哌利德更有效。测试。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2007年第9期|共4页
作者
Zhang R; Lei L; Xu YG; Hua WY; Gong GQ;
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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Physiological reperfusion; novel; Sodium measurement; inhibitors;

机译：生理性再灌注;新颖;钠测量;抑制剂;

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1. Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na(+)/H(+) exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury. [J] . Zhang R, Lei L, Xu YG, Bioorganic and Medicinal Chemistry Letters . 2007,第9期

机译：苯并咪唑-2-基或苯并咪唑-2-基硫代甲基苯甲酰胍作为新型Na（+）/ H（+）交换剂抑制剂，合成和针对缺血再灌注损伤的保护作用。
2. Synthesis and Bioactivity of Substituted Benzoylguanidine Derivatives as Potent Na＋/H＋ Exchanger Inhibitors [J] . Jin Ning, Yang Yun, Xu Wenting, 中国化学：英文版 . 2012,第002期

机译：取代的苯甲酰胍衍生物作为强Na + / H +交换抑制剂的合成及生物活性
3. Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors. [J] . Xu WT, Jin N, Xu J Bioorganic and Medicinal Chemistry Letters . 2009,第12期

机译：设计，合成和生物学评估新型取代的苯甲酰胍衍生物作为有效的Na + / H +交换抑制剂。
4. Corrosion Protection of the Modern Absorption Chillers in Geothermal Heat Exchangers using molybdate inhibitors [C] . S. Zolfaghari, A. Ashrafi, A. Saatchi, Associazione Italiana Di Metallurgia;Dechema;Annual event of the European Federation of Corrosion on European Corrosion Congress;uropean Federation of Corrosion . 2014

机译：钼酸盐缓蚀剂对地热换热器中现代吸收式制冷机的腐蚀防护
5. Fetuin inhibits TGF-beta-stimulated collagen synthesis and protection from apoptosis in activated hepatic stellate cells. [D] . Verma, Monica. 2001

机译：胎球蛋白在活化的肝星状细胞中抑制TGF-β刺激的胶原蛋白合成并防止细胞凋亡。
6. An evaluation of the neutrophil as a mediator of in vivo renal ischemic-reperfusion injury. [O] . M. A. Thornton, R. Winn, C. E. Alpers, 1989

机译：嗜中性粒细胞作为体内肾脏缺血再灌注损伤介质的评估。
7. The Effects of Different Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols on Cortical Gene Expression in a Rat Model of Cerebral Ischemic-Reperfusion Injury. [O] . Milos R Ljubisavljevic, Asma Javid, Joji Oommen, 2015

机译：不同重复经颅磁刺激（rTms）方案对大鼠脑缺血再灌注损伤皮质基因表达的影响。

Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na(+)/H(+) exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

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