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首页> 外文期刊>Journal of hepato-biliary-pancreatic surgery >Prophylaxis for septic complications in acute necrotizing pancreatitis.
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Prophylaxis for septic complications in acute necrotizing pancreatitis.

机译：预防急性坏死性胰腺炎的感染性并发症。

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Because the mortality of severe pancreatitis is higher when infected necrosis supervenes, prevention of infections has become a relevant endpoint for management. The "ideal" drug should be characterized by specific activity against the bacteria known to be responsible for infection and should be able to penetrate the gland in a sufficient concentration. To date there have been eight prospective trials with antibiotics, one on selective digestive decontamination, and others with enteral nutrition. A meta-analysis regarding experiences with antimicrobial drugs reports a significant reduction in the incidence of infected necrosis and pancreatic abscesses during severe pancreatitis. In conclusion, among the several options aimed at reducing infections during necrotizing pancreatitis, the prophylactic use of antibacterial drugs is the only one to have been tested to date in several randomized studies. Strong consideration should be given to treating patients with severe pancreatitis with broadspectrum antibiotics, selective digestive decontamination, and enteral nutrition.
机译：由于感染的坏死发生时严重胰腺炎的死亡率较高，因此预防感染已成为管理的相关终点。 “理想的”药物应具有针对已知引起感染的细菌的特异性活性，并应能够以足够的浓度穿透腺体。迄今为止，已有八项关于抗生素的前瞻性试验，一项关于选择性消化净化的研究，另一项关于肠内营养的试验。关于抗微生物药物经验的荟萃分析显示，严重胰腺炎期间感染性坏死和胰腺脓肿的发生率显着降低。总之，在旨在减少坏死性胰腺炎期间感染的几种选择中，迄今为止，在数项随机研究中仅对抗生素的预防性使用进行了测试。应大力考虑使用广谱抗生素，选择性消化净化和肠内营养治疗重症胰腺炎患者。

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