Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.

Cui YM; Yasutomi E; Otani Y; Yoshinaga T; Ido K; Sawada K; Kawahata M; Yamaguchi K; Ohwada T

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Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.

机译：12,14-二氯脱氢松香酸的新型肟和肟醚衍生物：设计，合成和BK通道开放活性。

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Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKalpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.

机译：合成了12,14-二氯脱氢松香酸的苄酮的肟醚衍生物（diCl-DHAA，4b），并在表达hBKalpha通道的CHO-K1细胞的分析系统中评估了其BK通道开放活性。 diCl-DHAA B环上的肟醚结构显着增加了BK通道开放活性。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2008年第24期|共4页
作者
Cui YM; Yasutomi E; Otani Y; Yoshinaga T; Ido K; Sawada K; Kawahata M; Yamaguchi K; Ohwada T;
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正文语种 eng
中图分类药学;生物化学;
关键词
large-conductance calcium-activated potassium channel; Oximes; Ethers; 12; 14-dichlorodehydroabietic acid; 肟类; 醚类;

机译：大电导钙激活钾通道;氧;醚;12;14-二氯脱氢松香酸;挥发性类;醚类;

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1. Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity. [J] . Cui YM, Yasutomi E, Otani Y, Bioorganic and Medicinal Chemistry Letters . 2008,第24期

机译：12,14-二氯脱氢松香酸的新型肟和肟醚衍生物：设计，合成和BK通道开放活性。
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Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity.

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