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首页> 外文期刊>Journal of hypertension >Use of calcium channel blockers is associated with better cognitive performance in older hypertensive patients with subjective memory complaints
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Use of calcium channel blockers is associated with better cognitive performance in older hypertensive patients with subjective memory complaints

机译：在患有主观记忆障碍的老年高血压患者中，使用钙离子通道阻滞剂可改善认知能力

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Background Hypertension is strongly associated with cognitive decline and a promising target for dementia prevention. Our aim was to investigate the association between different antihypertensive treatments and cognitive performance in elderly hypertensive patients presenting with subjective memory complaints.Patients and methods Three hundred and seventy-eight elderly hypertensive patients more than 60 years (mean age 70.4 +- 6.3 years) treated with at least one antihypertensive agent and presenting with subjective memory complaints but without dementia were prospectively recruited and underwent a combination of neuropsychological tests, brain magnetic resonance imaging with semiquantification of white matter hyperintensities, carotid echotracking, brachial endothelial function, and ambulatory blood pressure assessments.Results None of the three composite scores (memory score, verbal fluency, and visual memory capacity) was found associated with blood pressure levels. On the other hand, age-adjusted and sex-adjusted analyses showed a significant and positive association between memory score and use of calcium channel blockers (CCBs) (users: +0.14 +-0.09 versus nonusers: -0.12 +-0.06; P = 0.016). Multivariate analyses also revealed that CCB use was significantly associated with a better memory score, independently of age, male sex, white matter hyperintensities, and carotid wall cross-sectional area, all of which were associated with worse memory scores.Conclusion In elderly hypertensive treated patients with subjective memory complaints, CCB use was associated with better memory performance independently of blood pressure level and macrovascular and microvascular alterations, suggesting a specific neuroprotective effect of this pharmacological class. Interventional controlled trials are required to confirm the specific protective effect of CCBs on cognitive decline.
机译：背景高血压与认知能力下降密切相关，是预防痴呆症的有希望的目标。我们的目的是调查患有主观记忆障碍的老年高血压患者，不同的降压治疗方法与认知能力之间的关系。患者和方法378例年龄超过60岁（平均年龄70.4±6.3岁）的老年高血压患者前瞻性地招募了具有至少一种降压药且主观记忆障碍但没有痴呆症的人，并进行了神经心理学测试，脑磁共振成像，白质高信号半定量，颈动脉回声追踪，肱动脉内皮功能和动态血压评估。结果三个综合评分（记忆评分，口语流利度和视觉记忆能力）均未发现与血压水平相关。另一方面，经过年龄调整和性别调整的分析显示，记忆力得分与使用钙通道阻滞剂（CCB）之间存在显着正相关（使用者：+0.14 + -0.09，而非使用者：-0.12 + -0.06; P = 0.016）。多变量分析还显示，使用CCB与更好的记忆力得分显着相关，而与年龄，男性，白质高信号和颈动脉壁横截面积无关，所有这些都与较差的记忆力得分相关。对于有主观记忆障碍的患者，使用CCB与更好的记忆表现无关，而与血压水平以及大血管和微血管改变无关，这表明该药理学类别具有特定的神经保护作用。需要进行干预性对照试验以确认CCB对认知能力下降的特定保护作用。

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