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首页> 外文期刊>Journal of Hepatology: The Journal of the European Association for the Study of the Liver >Reply to Triple or dual therapy for HCV-1 naive patients? Optimizing selection tools
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Reply to Triple or dual therapy for HCV-1 naive patients? Optimizing selection tools

机译：回复针对HCV-1初治患者的三重或双重治疗？优化选择工具

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We read with interest the paper by Andriulli et al. [1] about the identification of naive HCV-1 patients who can be treated with dual therapy according to baseline and on-treatment parameters.Important predictive factors of sustained virological response (SVR) are the IL28B single-nucleotide polymorphisms (SNPs), however the authors considered only the rsl2979860 SNP, forgetting the more important rs8099917 [2-4]; this is, in our opinion, not just an academic discussion, because the role of rs8099917 has been clarified and deepened in several studies and we think it should be included as best SVR predictor in the genotype 1 [2-4]. The major impact of rsl2979860 has been documented on the early response [5], while rs8099917 in a recent meta-analysis evidenced the best predictive effect on the SVR (OR = 5.171 vs. 4.473) [6]. In fact, the effect of this SNP explains the higher rate of relapse in patients who achieved both RVR and ETR with the CC rsl2979860 genotype, but with the presence of a G allele for the rs8099917 SNP [5]. Conversely, patients without the CC genotype for rsl2979860 retain good probability to reach SVR if they have the TT genotype for rs8099917; this issue could underlie the high rate of SVR in non-CC patients reported by Andriulli et al. [1] and according with the TT prevalence in the Italian population. Therefore, we consider it essential to get both rsl 2979860 and rs8099917 SNPs as predictors on SVR and, in more detail, we could select the patients with CC/TT or CT/TT, but not with CC/TG or CC/GG genotype, for dual therapy.
机译：我们感兴趣地阅读了Andriulli等人的论文。 [1]关于鉴定可以根据基线和治疗参数接受双重疗法治疗的初次HCV-1患者。持续病毒学应答（SVR）的重要预测因素是IL28B单核苷酸多态性（SNP）。作者只考虑了rsl2979860 SNP，却忘记了更重要的rs8099917 [2-4]。在我们看来，这不仅仅是学术讨论，因为rs8099917的作用已在一些研究中得到了阐明和加深，我们认为它应作为基因型1的最佳SVR预测因子纳入[2-4]。 rsl2979860的主要影响已被记录在早期反应中[5]，而在最近的荟萃分析中，rs8099917证明了对SVR的最佳预测效果（OR = 5.171 vs. 4.473）[6]。实际上，这种SNP的作用解释了CC rsl2979860基因型同时实现RVR和ETR且rs8099917 SNP存在G等位基因的患者复发率更高[5]。相反，没有rsl2979860的CC基因型的患者，如果他们具有rs8099917的TT基因型，则保留了达到SVR的良好可能性。这个问题可能是Andriulli等人报道的非CC患者高SVR的原因。 [1]并与TT患病率在意大利人口中一致。因此，我们认为必须同时获得rsl 2979860和rs8099917 SNP作为SVR的预测指标，并且更详细地，我们可以选择CC / TT或CT / TT的患者，而不选择CC / TG或CC / GG基因型的患者，用于双重疗法。

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