Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers.

Kurtz M; Black Golde P; Berlinger N

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Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers.

机译：可待因处方母乳喂养母亲在CYP2D6基因型测试中的道德考量。

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In this issue, Madadi et al. report on interviews with codeine-prescribed breastfeeding mothers concerning preferences and attitudes toward receiving their CYP2D6 genotype and overall study findings. We address three sets of ethics questions raised by this article. Should genetic information be disclosed to research participants in genetic research? What should clinicians take into account when considering this genetic test in managing infant opioid toxicity risk? What conditions support or hinder the integration of genetic information into patient care?

机译：在本期中，Madadi等人。报告关于接受可待因处方的母乳喂养母亲的访谈，这些访谈涉及他们对接受CYP2D6基因型的偏好和态度以及总体研究结果。我们将解决本文提出的三套道德问题。是否应向遗传研究的研究参与者披露遗传信息？在管理婴儿阿片类药物毒性风险时，临床医生在考虑进行这项基因检测时应考虑哪些因素？哪些条件支持或阻碍将遗传信息整合到患者护理中？

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《Clinical Pharmacology and Therapeutics》 |2010年第6期|共3页
作者
Kurtz M; Black Golde P; Berlinger N;
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正文语种 eng
中图分类药理学;
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1. Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers. [J] . Kurtz M, Black Golde P, Berlinger N Clinical Pharmacology and Therapeutics . 2010,第6期

机译：可待因处方母乳喂养母亲在CYP2D6基因型测试中的道德考量。
2. PK/PD modeling of rabeprazole in CYP2C19 genotypes: consideration of the influence of thio-ether metabolite, CYP3A4, accumulation and CYP2D6 polymorphism may help to better develop and validate the model. [J] . Srinivas NR European journal of clinical pharmacology . 2011,第9期

机译：雷贝拉唑在CYP2C19基因型中的PK / PD建模：考虑硫醚代谢物，CYP3A4，积累和CYP2D6多态性的影响可能有助于更好地开发和验证模型。
3. PK/PD modeling of rabeprazole in CYP2C19 genotypes: consideration of the influence of thio-ether metabolite, CYP3A4, accumulation and CYP2D6 polymorphism may help to better develop and validate the model [J] . Nuggehally R. Srinivas European Journal of Clinical Pharmacology . 2011,第9期

机译：雷贝拉唑在CYP2C19基因型中的PK / PD建模：考虑硫醚代谢物，CYP3A4，积累和CYP2D6多态性的影响可能有助于更好地开发和验证模型
4. Usability Testing an Electronic Health Record: Lessons Learned and Ethical Considerations [C] . Helen J.A. Fuller, Kyle D. Maddox, Nancy J. Lightner International Conference on Applied Human Factors and Ergonomics . 2017

机译：可用性测试电子健康记录：经验教训和道德考虑
5. Testing and selecting drought resistant common bermudagrass genotypes [D] . Liu, Yichen 2013

机译：测试和选择抗旱常见的百慕大基因型
6. Significantly lower CYP2D6 metabolism measured as the O/N‐desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients [O] . Tore Haslemo, Erik Eliasson, Marin M. Jukić, 2019

机译：以CYP2D6 * 41与CYP2D6 * 9或CYP2D6 * 10的携带者的O / N-去甲基文拉法辛代谢率衡量的CYP2D6代谢显着降低：一项针对1003位基因型斯堪的纳维亚患者的治疗药物监测数据的研究
7. Significantly lower CYP2D6 metabolism measured as the O/N ‐desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10 : a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients [O] . Tore Haslemo, Erik Eliasson, Marin M. Jukić, 2018

机译：CYP2D6 * 41载体与CYP2D6 * 9或CYP2D6 * 10的载体中测量的CYP2D6代谢测量的CYP2D6代谢测量结果：来自1003个基因分型斯堪纳维亚患者的治疗药物监测数据的研究

Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers.

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