Synthesis, crystal structure, and fungicidal activity of novel 1,5-diaryl-1H-pyrazol-3-Oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties

Liu Y.; He G.; Kai C.; Li Y.; Zhu H.

首页> 外文期刊>Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry >Synthesis, crystal structure, and fungicidal activity of novel 1,5-diaryl-1H-pyrazol-3-Oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties

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Synthesis, crystal structure, and fungicidal activity of novel 1,5-diaryl-1H-pyrazol-3-Oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties

机译：新型含氧乙酸或氧（2-硫代噻唑并恶唑烷-3-基）乙酮部分的新型1,5-二芳基-1H-吡唑-3-氧代衍生物的合成，晶体结构和杀真菌活性

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A series of novel 1,5-diaryl-1H-pyrazol-3-oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties were prepared from methyl 3-arylacrylates via a serial of reactions included addition-cyclization, oxidation, substitution, hydrolysis, and condensation. Their structures were confirmed by 1H-NMR, 13C-NMR, IR, and elemental analysis. In addition, the crystal structure of the compound 2-(1,5-diphenyl-1H-pyrazol-3-yloxy)-1-(2-thioxothiazolidin-3-yl)ethanone was determined by single crystal X-ray diffraction analysis. Bioassay results indicated that the compound 2-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yloxy)- 1-(2-thioxo-thiazolidin-3-yl)ethanone exhibited moderate inhibitory activity against Gibberella zeae at the dosage of 10 μg mL-1.

机译：由3-芳基丙烯酸甲酯通过包括加成环化在内的一系列反应制备了一系列含有氧乙酸或氧（2-硫代噻唑并恶唑烷-3-基）乙酮部分的新型1,5-二芳基-1H-吡唑-3-氧衍生物，氧化，取代，水解和缩合。通过1 H-NMR，13 C-NMR，IR和元素分析证实了它们的结构。另外，通过单晶X射线衍射分析确定了化合物2-（1，5-二苯基-1H-吡唑-3-基氧基）-1-（2-硫代噻唑啉酮-3-基）乙酮的晶体结构。生物测定结果表明，化合物2-（5-（4-氯苯基）-1-苯基-1H-吡唑-3-基氧基）-1-（2-硫代-噻唑烷--3-基）乙酮对赤霉素具有中等抑制作用剂量为10μgmL-1的玉米。

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《Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry》 |2012年第6期|共6页
作者
Liu Y.; He G.; Kai C.; Li Y.; Zhu H.;
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Synthesis, crystal structure, and fungicidal activity of novel 1,5-diaryl-1H-pyrazol-3-Oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3-yl)ethanone moieties

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