Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A.

Ogawa S; Morikawa T

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Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A.

机译：三种甘露他汀A脱氧衍生物的α-甘露糖苷酶抑制活性的合成和生物学评估。

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摘要

Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitors activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity.

机译：合成了三种α-甘露糖苷酶抑制剂甘露他汀A的脱氧衍生物，并评估了它们对Jack beanα-甘露糖苷酶的抑制剂活性，以阐明抑制剂中每个羟基的作用。1-和2-脱氧衍生物虽然保留了抑制电位，与母体相比降低了一百倍的活性，但是3-脱氧衍生物失去了活性。

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《Bioorganic and Medicinal Chemistry Letters》 |1999年第11期|共6页
作者
Ogawa S; Morikawa T;
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正文语种 eng
中图分类药学;生物化学;
关键词
Cyclopentanes; Mannosidases; alpha mannosidase; 1-deoxymannostatin A; 2-deoxymannostatin A; 环戊烷类; 甘露糖苷酶类;

机译：Cyclopentanes;Mannosidases;alpha mannosidase;1-deoxymannostatin A;2-deoxymannostatin A;环戊烷类;甘露糖苷酶类;

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1. Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A. [J] . Ogawa S, Morikawa T Bioorganic and Medicinal Chemistry Letters . 1999,第11期

机译：三种甘露他汀A脱氧衍生物的α-甘露糖苷酶抑制活性的合成和生物学评估。
2. Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the alpha-glucosidase inhibitory activity. [J] . Muraoka O, Yoshikai K, Takahashi H, Bioorganic and medicinal chemistry . 2006,第2期

机译：合成和脱氧水杨醇的生物学评估，极性取代基在侧链上对α-葡萄糖苷酶抑制活性的作用。
3. Synthesis and biological evaluation of deoxy salacinols, the role of polar substituents in the side chain on the alpha-glucosidase inhibitory activity. [J] . Muraoka O, Yoshikai K, Takahashi H, Bioorganic and Medicinal Chemistry . 2006,第2期

机译：合成和脱氧水杨醇的生物学评估，极性取代基在侧链上对α-葡萄糖苷酶抑制活性的作用。
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Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A.

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