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首页> 外文期刊>Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy >Analysis of molecular epidemiologic characteristics of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli colonizing feces in hospital patients and community dwellers in a Japanese city
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Analysis of molecular epidemiologic characteristics of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli colonizing feces in hospital patients and community dwellers in a Japanese city

机译：在日本城市的住院患者和社区居民中，产生广谱β-内酰胺酶（ESBL）的大肠杆菌定殖粪便的分子流行病学特征分析

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摘要

Infectious diseases caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are prevalent because of nosocomial infection. In addition, colonization of ESBL-producing E. coli in the intestinal tract of community dwellers due to the contamination of meat or environmental water is assumed to be one of the sources, but the causes have not been clarified. To analyze these factors, we investigated the difference in clonal groups using a combination of phylogenetic groups and multilocus sequence typing of ESBL-producing E. coli, which were obtained from the feces of an inpatient group in our hospital and a community-dwelling group living in a Japanese city. The carriage rate of ESBLproducing E. coil in the inpatient group was 12.5% (32/257), similar to that of 8.5% (42/496) in the community dwellers (P = 0.082). Of the ESBL clonal groups detected from the community dwellers, 52% (22/42) were clonal groups, including D-ST1485, D-ST70, D-ST2847, B2-ST550, B2-ST3510, A-ST93, AST580, A-ST716 and Bl-ST2787, that have not been detected from human pathogens, meat, companion animals and environmental water, whereas all clonal groups detected from the inpatients were those that had already been reported. The rate of fluoroquinolone-resistant ESBL clonal groups colonizing the intestinal tract of the inpatient group rose as the number of hospital days increased. These results indicated that different factors were related to colonization of ESBL-producing E. coli in the feces of the inpatient group and the community-dwelling group. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
机译：由于医院内感染，由产生广谱β-内酰胺酶（ESBL）的大肠杆菌引起的感染性疾病十分普遍。另外，由于肉或环境水的污染，在社区居民的肠道中产生ESBL的大肠杆菌的定殖被认为是其中一种来源，但其原因尚未阐明。为了分析这些因素，我们使用系统发生群和产ESBL大肠杆菌的多基因座序列类型的组合调查了克隆群之间的差异，这是从我院住院组和社区居住组的粪便中获得的在日本城市。住院组中产生ESBL的大肠杆菌的携带率为12.5％（32/257），与社区居民的携带率为8.5％（42/496）（P = 0.082）。在从社区居民中检测到的ESBL克隆组中，有52％（22/42）是克隆组，包括D-ST1485，D-ST70，D-ST2847，B2-ST550，B2-ST3510，A-ST93，AST580，A -ST716和B1-ST2787尚未从人类病原体，肉，伴侣动物和环境水中检出，而从住院患者中检出的所有克隆组均已报道。随着住院天数的增加，对氟喹诺酮类耐药的ESBL克隆组在住院组肠道中的扩散率上升。这些结果表明，不同的因素与住院组和社区居住组的粪便中产生ESBL的大肠杆菌的定殖有关。 （C）2015年，日本化学治疗学会和日本传染病协会。由Elsevier Ltd.出版。保留所有权利。

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