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首页> 外文期刊>Journal of human nutrition and dietetics >What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions.
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What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions.

机译：我们应该增加哪些干预措施来减轻肥胖成人的减肥饮食？对增加药物治疗，运动，行为治疗或这些干预措施组合的随机对照试验的系统评价。

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Abstract Background Evidence is needed for the effectiveness of interventions given with reducing diets for obese adults: drug therapy, exercise, or behaviour therapy. Methods We systematically reviewed randomized controlled trials in any language. We searched 13 databases and handsearched journals. Trials lasted 1 year or more. One investigator extracted data and a second checked data extraction. Trial quality was assessed. Results Adding orlistat to diet was associated with weight change for up to 24 months (-3.26 kg, 95% CI, -4.15 to -2.37 kg), and statistically significant beneficial changes were found for total and LDL cholesterol, blood pressure and glycaemic control. Adding sibutramine to diet was associated with a 12 month weight change of -4.18 kg (95% CI, -5.14 to -3.21 kg), and statistically significant beneficial effects on high density lipoprotein cholesterol (HDL) and triglycerides (TGs), but an increase in diastolic blood pressure. Adding exercise to diet, or to diet and behaviour therapy, was associated with improved weight loss for up to 36 months and improvements in HDL, TGs and blood pressure. Adding behaviour therapy to diet, or to diet and sibutramine together, was associated with improved weight loss for up to 18 months. Adding drugs, exercise or behaviour therapy to dietary advice was each associated with similar weight change. Conclusions Adding orlistat, sibutramine, exercise, or behaviour modification to dietary advice can improve long-term weight loss.
机译：摘要背景需要证据证明减少肥胖成年人饮食的干预措施的有效性：药物治疗，运动或行为治疗。方法我们系统地审查了任何语言的随机对照试验。我们搜索了13个数据库并手工搜索了期刊。试用期持续1年或更长时间。一名研究人员提取了数据，第二次检查了数据。评估审判质量。结果在饮食中添加奥利司他与体重变化长达24个月有关（-3.26 kg，95％CI，-4.15至-2.37 kg），并且在总胆固醇和LDL胆固醇，血压和血糖控制方面发现统计学上显着的有益变化。 。在饮食中添加西布曲明与12个月体重变化-4.18 kg（95％CI，-5.14至-3.21 kg）相关，并且对高密度脂蛋白胆固醇（HDL）和甘油三酸酯（TGs）具有统计学上的显着有益作用，但是舒张压升高。在饮食中增加运动，或在饮食和行为治疗中增加体重减轻长达36个月，并改善HDL，TG和血压。在饮食中添加行为疗法，或在饮食中加入西布曲明，与减肥相结合最多可以持续18个月。在饮食建议中添加药物，运动或行为疗法均与体重减轻相似。结论在饮食建议中添加奥利司他，西布曲明，运动或行为改变可以改善长期体重减轻。

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