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首页> 外文期刊>Journal of Infection >Diagnostic performance of an enzyme-linked immunospot assay for interferon-gamma in extrapulmonary tuberculosis varies between different sites of disease.
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Diagnostic performance of an enzyme-linked immunospot assay for interferon-gamma in extrapulmonary tuberculosis varies between different sites of disease.

机译：酶联免疫斑点法对肺外结核中γ干扰素的诊断性能在疾病的不同部位之间有所不同。

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OBJECTIVES: To evaluate diagnostic performance of an enzyme-linked immunospot assay for interferon-gamma (T SPOT-TB) in patients with suspected extrapulmonary tuberculosis (TB). METHODS: From January 2007 to December 2008, patients with suspected extrapulmonary TB were prospectively enrolled from 2 tertiary care hospitals. RESULTS: A total of 138 patients with suspected extrapulmonary TB were enrolled; 50 patients had positive culture for Mycobacterium tuberculosis and 39 patients had probable TB. The sites of infection were lymph node (n = 20), pleura (n = 19), bone/joint (n = 15), urinary tract (n = 7), peritoneum (n = 7), meninges (n = 6), disseminated (n = 5), intestine (n = 3), pericardium (n = 2), skin (n = 2), throat (n = 1), neck (n = 1), and genitalia (n = 1). The overall sensitivity and specificity were 79.8% (71/89) and 81.6% (40/49). The sensitivity ranged from 100% for tuberculous meningitis, tuberculous pericarditis, and intestinal TB, 95% for lymphadenitis, to 42.9% for tuberculous peritonitis. The sensitivity of the T SPOT-TB assay was 70.6% in immunocompromised patients and 85.5% in immunocompetent patients (p = 0.09). CONCLUSIONS: The T SPOT-TB assay can be a useful tool for diagnosing extra-pulmonary TB in immunocompetent and immunocompromised patients, particularly for tuberculous meningitis, pericarditis, lymphadenitis, and intestinal TB.
机译：目的：评估酶联免疫斑点法对疑似肺外结核（TB）患者的γ-干扰素（T SPOT-TB）的诊断性能。方法：从2007年1月至2008年12月，前瞻性从2家三级医院入选了疑似肺外结核患者。结果：总共招募了138名怀疑肺外结核患者。 50例结核分枝杆菌培养阳性，39例可能结核。感染部位为淋巴结（n = 20），胸膜（n = 19），骨/关节（n = 15），尿路（n = 7），腹膜（n = 7），脑膜（n = 6） ，散布（n = 5），肠（n = 3），心包（n = 2），皮肤（n = 2），喉咙（n = 1），脖子（n = 1）和生殖器（n = 1） 。总体敏感性和特异性分别为79.8％（71/89）和81.6％（40/49）。敏感性的范围从结核性脑膜炎，结核性心包炎和肠结核的100％，淋巴结炎的95％到结核性腹膜炎的42.9％不等。 T SPOT-TB检测的敏感性在免疫功能低下的患者中为70.6％，在免疫功能正常的患者中为85.5％（p = 0.09）。结论：T SPOT-TB测定法可用于诊断免疫能力强和免疫功能低下的患者，尤其是结核性脑膜炎，心包炎，淋巴结炎和肠结核的肺外结核。

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