Novel naphthyridines are histamine H(3) antagonists and serotonin reuptake transporter inhibitors.

Letavic MA; Keith JM; Ly KS; Barbier AJ; Boggs JD; Wilson SJ; Lord B; Lovenberg TW; Carruthers NI

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Novel naphthyridines are histamine H(3) antagonists and serotonin reuptake transporter inhibitors.

机译：新型萘啶是组胺H（3）拮抗剂和血清素再摄取转运蛋白抑制剂。

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A series of novel tetrahydronaphthyridine-based histamine H(3) ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.

机译：描述了一系列具有血清素再摄取转运蛋白抑制剂活性的新型基于四氢萘啶的组胺H（3）配体。 1,2,3,4-四氢-2,6-萘啶骨架是通过向金属化吡啶中添加硝基苯乙烯，然后还原并环化形成萘啶而组装的。讨论了这些新型化合物的体外生物学数据。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2007年第9期|共4页
作者
Letavic MA; Keith JM; Ly KS; Barbier AJ; Boggs JD; Wilson SJ; Lord B; Lovenberg TW; Carruthers NI;
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正文语种 eng
中图分类药学;生物化学;
关键词
naphthyridine; reuptake; Membrane Transport Proteins; Serotonin; 血清素;

机译：naphthyridine;reuptake;Membrane Transport Proteins;Serotonin;血清素;

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1. Novel naphthyridines are histamine H(3) antagonists and serotonin reuptake transporter inhibitors. [J] . Letavic MA, Keith JM, Ly KS, Bioorganic and Medicinal Chemistry Letters . 2007,第9期

机译：新型萘啶是组胺H（3）拮抗剂和血清素再摄取转运蛋白抑制剂。
2. Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors. [J] . Letavic MA, Keith JM, Jablonowski JA, Bioorganic and Medicinal Chemistry Letters . 2007,第4期

机译：新型四氢异喹啉是组胺H3拮抗剂和5-羟色胺再摄取抑制剂。
3. Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors. [J] . Letavic MA, Stocking EM, Barbier AJ, Bioorganic and Medicinal Chemistry Letters . 2007,第17期

机译：苄胺组胺H（3）拮抗剂和5-羟色胺再摄取抑制剂。
4. SEROTONIN RECEPTOR AND SEROTONIN REUPTAKE TRANSPORTER EXPRESSION IN PRIMARY AND METASTATIC CANINE OSTEOSARCOMA CELL LINES. [C] . Shay Bracha, Kenine E Comstock, Evan T Keller, Annual conference of the Veterinary Cancer Society . 2008

机译：血清素受体和血清素再摄取转运蛋白表达在原发性和转移性犬骨瘤细胞系中。
5. Serotonin Receptor Signaling Following Selective Serotonin Reuptake Inhibitor Treatment or: How I Learned to Stop Worrying and Love the Agonist. [D] . Van Dyke, Adam M. 2016

机译：选择性5-羟色胺再摄取抑制剂治疗后的5-羟色胺受体信号，或：我如何学会停止担心和热爱激动剂。
6. Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows [O] . Theodore W. Valenti Jr., Georgianna G. Gould, Jason P. Berninger, -1

机译：人类血浆治疗的选择性5-羟色胺再摄取抑制剂的水平（ssRI）舍曲林降低血清素再摄取转运绑定和成年雄性黑头呆鱼庇护寻求行为
7. Depression in primary care: interpersonal counseling vs selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design. [O] . Menchetti M, Bortolotti B, Rucci P, 2011

机译：初级保健中的抑郁症：人际咨询与选择性5-羟色胺再摄取抑制剂的关系。 DEPICS研究。多中心随机对照试验。基本原理和设计。

Novel naphthyridines are histamine H(3) antagonists and serotonin reuptake transporter inhibitors.

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