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首页> 外文期刊>Clinical physiology >Distribution of interstitial fluid pressure and fluid volumes in hind-limb skin of rats: relation to meridians?
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Distribution of interstitial fluid pressure and fluid volumes in hind-limb skin of rats: relation to meridians?

机译：大鼠后肢皮肤间质液压力和液量的分布：与经络的关系？

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To determine the distribution of interstitial fluid pressure (Pi) and volume (Vi), and to relate the distribution of these parameters to the distribution of potential meridians located by measurement of electrical impedance, we measured Pi, extracellular fluid (Ve) and plasma volumes (Vp) in 14 pre-defined skin areas, 2 x 2 mm, and in concave and convex regions on the hind-limb and groin of rats in control conditions. Pi was measured with sharpened glass capillaries connected to a servo-controlled counter-pressure system, while Ve and Vp were determined as the extravascular distribution spaces of 51Cr-EDTA and 125I-human serum albumin, respectively. Vi was calculated as Ve - Vp, and Vw as the difference between skin wet and dry weight. Grand mean Pi averaged -0.81 mmHg (SD 0.83, n=95). Pi in skin was significantly higher in lateral and medial parts of the medial aspect of hind-limb compared to pressures in the intermediate area (P<0.05). Pressures in the concave groin and the convex knee area were more negative and positive, respectively, than in the flat intermediate central hind-limb area. There was a significantly higher Vi (P<0.05) and Vw (P<0.05) in the lateral side than that in the medial side. Vp was higher medially and laterally than in the intermediate area (P<0.05 for both comparisons), and correlated positively and significantly with Pi (r=0.66, P<0.05). No correlation was found between Pi and electrical impedance. The study suggests that the distribution of Pi, Vi, Vp and Vw is heterogeneous in hind-limb skin at a macroscopic level without obvious relations to potential meridians.
机译：为了确定组织液压力（Pi）和体积（Vi）的分布，并使这些参数的分布与通过测量电阻抗确定的潜在子午线的分布相关，我们测量了Pi，细胞外液（Ve）和血浆体积（Vp）在对照条件下大鼠的14个预定皮肤区域（2 x 2毫米）以及后肢和腹股沟的凹凸区域。用连接到伺服控制的反压系统的尖锐玻璃毛细管测量Pi，而将Ve和Vp分别确定为51Cr-EDTA和125I-人血清白蛋白的血管外分布空间。 Vi计算为Ve-Vp，Vw计算为皮肤干湿重之间的差。总平均Pi平均为-0.81 mmHg（SD 0.83，n = 95）。与中间区域的压力相比，后肢内侧的外侧和内侧部分的皮肤中的Pi显着更高（P <0.05）。凹腹股沟和凸膝区域的压力分别比平坦的中间中央后肢区域的负压力和正压力大。外侧的Vi（P <0.05）和Vw（P <0.05）明显高于内侧。 Vp在内侧和外侧均高于中间区域（两个比较均P <0.05），并且与Pi呈正相关且显着相关（r = 0.66，P <0.05）。在Pi和电阻抗之间未发现相关性。研究表明，从宏观角度看，Pi，Vi，Vp和Vw在后肢皮肤中的分布是异质的，与潜在子午线没有明显的关系。

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