Synthesis and characterization of water-soluble, heteronuclear ruthenium(III)/ferrocene complexes and their interactions with biomolecules

Anderson Craig M.; Jain Swapan S.; Silber Lisa; Chen Kody; Guha Sumedha; Zhang Wancong; McLaughlin Emily C.; Hu Yongfeng; Tanski Joseph M.

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Synthesis and characterization of water-soluble, heteronuclear ruthenium(III)/ferrocene complexes and their interactions with biomolecules

机译：水溶性异核钌（III）/二茂铁配合物的合成，表征及其与生物分子的相互作用

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The reaction of Na[RuCl4(SO(CH3)(2))(2)], 1, with one equivalent of FcCONHCH(2)C(6)H(4)N (Fc = FeC10H9), L1, FcCOOCH(2)CH(2)C(3)H(3)N(2), L2, FcCOOC(6)H(4)N, L3, afforded the dinuclear species, Na[FcCONHCH(2)C(6)H(4)N [RuCl4(SO(CH3)(2))]], RuL1, Na[FcCOOCH(2)CH(2)C(3)H(3)N(2)[RuCl4(SO(CH3)(2))]], RuL2, Na[FcCOOC(6)H(4)N (RuCl4(SO(CH3)(2)))], RuL3, respectively, yielding, in each case, a ferrocene moiety bridged to a ruthenium center. The complexes were characterized by NMR, IR, and XRD (X-ray diffraction). The sulfoxide ligands are bonded to the metal through the sulfur atom. The complexes were evaluated for their biological activity with pBluescript DNA plasmid, and the protein BSA (bovine serum albumin). These reactions were monitored by XAS (X-ray absorption spectroscopy), EXAFS (extended X-ray Absorption Fine Structure), NMR, UV/visible, emission spectroscopy, and gel electrophoresis. Donor atoms from the biomolecules substitute for the chloride ligands in the parent complexes. (C) 2015 Elsevier Inc. All rights reserved.

机译：Na [RuCl4（SO（CH3）（2））（2）]，1，与一当量的FcCONHCH（2）C（6）H（4）N（Fc = FeC10H9），L1，FcCOOCH（2 ）CH（2）C（3）H（3）N（2），L2，FcCOOC（6）H（4）N，L3，提供双核物质Na [FcCONHCH（2）C（6）H（4））N [RuCl4（SO（CH3）（2））]，RuL1，Na [FcCOOCH（2）CH（2）C（3）H（3）N（2）[RuCl4（SO（CH3）（2）））]]，RuL2，Na [FcCOOC（6）H（4）N（RuCl4（SO（CH3）（2）））]，RuL3分别在每种情况下产生桥连至钌中心的二茂铁部分。通过NMR，IR和XRD（X射线衍射）表征复合物。亚砜配体通过硫原子与金属键合。用pBluescript DNA质粒和蛋白质BSA（牛血清白蛋白）评估了复合物的生物学活性。这些反应通过XAS（X射线吸收光谱法），EXAFS（扩展的X射线吸收精细结构），NMR，UV /可见光，发射光谱和凝胶电泳进行监测。来自生物分子的供体原子替代了母体复合物中的氯配体。（C）2015 Elsevier Inc.保留所有权利。

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《Journal of Inorganic Biochemistry: An Interdisciplinary Journal》 |2015年第null期|共10页
作者
Anderson Craig M.; Jain Swapan S.; Silber Lisa; Chen Kody; Guha Sumedha; Zhang Wancong; McLaughlin Emily C.; Hu Yongfeng; Tanski Joseph M.;
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正文语种 eng
中图分类生物化学;
关键词
Cancer; Ferrocene; Ruthenium; Paramagnetic; NMR;

机译：癌症;二茂铁;钌;顺磁性;NMR;

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Synthesis and characterization of water-soluble, heteronuclear ruthenium(III)/ferrocene complexes and their interactions with biomolecules

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