...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of industrial and engineering chemistry >Prediction and characterization of drug release in a multi-drug release system
【24h】

Prediction and characterization of drug release in a multi-drug release system

机译：多种药物释放系统中药物释放的预测和表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new drug delivery system (DDS) was prepared by electrospinning and multi-layered coating methods. Lactobacillus was used as a target drug for release in the large intestine. Lactobacillus was incorporated into polyvinyl alcohol-based electrospun fibers. Alginate and chitosan were then used to coat these fibers to protect and deliver lactobacillus to the large intestine. The multi-layered coating procedure was carried out at various coating times to determine the optimal coating amount in human digestion conditions. The drug-release experiment was conducted using an in vitro model of human digestion processes. Chitosan and alginate were released by dissolving in acid and neutral conditions, respectively. Lactobacillus was then released in a large intestine model by the hydrogel swelling effects of PVA-based electrospun fibers. The drug-release behavior was predicted by calculated equations for optimized coating times. Eventually, the lactobacillus was effectively delivered to the target large intestine by chitosan and alginate coating and was released by PVA hydrogel swelling.
机译：通过静电纺丝和多层包衣方法制备了一种新的药物递送系统（DDS）。乳酸杆菌用作在大肠中释放的靶标药物。将乳酸杆菌掺入基于聚乙烯醇的电纺丝纤维中。然后使用藻酸盐和壳聚糖包被这些纤维，以保护乳酸菌并将其转移至大肠。在不同的涂布时间进行多层涂布程序，以确定在人体消化条件下的最佳涂布量。使用人体消化过程的体外模型进行了药物释放实验。壳聚糖和藻酸盐分别通过溶解在酸性和中性条件下释放。乳酸菌随后通过基于PVA的电纺纤维的水凝胶溶胀作用在大肠模型中释放。通过优化的包衣时间的计算方程可预测药物释放行为。最终，乳酸菌通过壳聚糖和藻酸盐包衣被有效地递送至目标大肠，并通过PVA水凝胶溶胀而释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号