...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of industrial and engineering chemistry >Increase of degradation and water uptake rate using electrospun star-shaped poly(D,L-lactide) nanofiber
【24h】

Increase of degradation and water uptake rate using electrospun star-shaped poly(D,L-lactide) nanofiber

机译：使用电纺星形聚（D，L-丙交酯）纳米纤维提高降解和吸水率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Conventional poly(D,L-lactide) (PLA)-based scaffolds have limited in biomedical applications because they inherently have long degradation time, strong stiffness, and hydrophobicity. This study presents a novel approach for solving the technical issues using electrospun nanofiber of star-shaped PLA. The nanofibers can be substantially altered by the control of number arms in monomer unit. The electrospun scaffolds based on the star-shaped PLA polymers, comprised of randomly interconnected webs of sub-micron sized fibers. In this study, the effects of PLA polymers with different branched arms on the rate of water uptake and biodegradation of electrospun scaffolds are investigated. The hydrophilicity of electrospun PLA nanofibers, as determined by rate of water uptake, is dramatically increased. In addition, in vitro degradation study clearly confirms that the electrospun nanofiber having 3-branched arms shows the 75% weight loss in 3 days, which suggest that the electrospun nanofiber with 3 arms-monomer is most easily degradable one. The selection of branched PLA combined with the non-invasive electrospinning process is useful in the synthesis of a novel kind of biodegradable scaffolds suitable for different biomedical applications because of easy control of porosity, mechanical flexibility, higher water uptake, and biodegradability.
机译：常规的基于聚（D，L-丙交酯）（PLA）的支架在生物医学应用中受到限制，因为它们固有地具有长的降解时间，强的刚度和疏水性。这项研究提出了一种新的方法来解决使用星形PLA静电纺丝纳米纤维的技术问题。可以通过控制单体单元中的数臂来实质上改变纳米纤维。基于星形PLA聚合物的电纺支架，由亚微米尺寸纤维的随机互连网组成。在这项研究中，研究了具有不同分支臂的PLA聚合物对静电纺丝支架的吸水率和生物降解率的影响。由吸水率决定的电纺PLA纳米纤维的亲水性大大提高。另外，体外降解研究清楚地证实具有3个分支臂的电纺纳米纤维在3天内显示出75％的重量损失，这表明具有3个臂单体的电纺纳米纤维是最容易降解的。支链PLA的选择与非侵入性静电纺丝工艺相结合，由于易于控制孔隙率，机械柔韧性，较高的吸水率和生物降解性，因此在合成适用于不同生物医学应用的新型可生物降解支架时非常有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号