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首页> 外文期刊>Journal of Lipid Research >Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation.
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Specific phospholipid fatty acid composition of brain regions in mice. Effects of n-3 polyunsaturated fatty acid deficiency and phospholipid supplementation.

机译：小鼠大脑区域的特定磷脂脂肪酸组成。 n-3多不饱和脂肪酸缺乏症和磷脂补充的影响。

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This study examined the effects of dietary alpha-linolenic acid deficiency followed or not by supplementation with phospholipids rich in n;-3 polyunsaturated fatty acid (PUFA) on the fatty acid composition of total phospholipids in 11 brain regions. Three weeks before mating, mice were fed a semisynthetic diet containing both linoleic and alpha-linolenic acid or deficient in alpha-linolenic acid. Pups were fed the same diet as their dams. At the age of 7 weeks, a part of the deficient group were supplemented with n;-3 polyunsaturated fatty acids (PUFA) from either egg yolk or pig brain phospholipids for 2 months. Saturated and monounsaturated fatty acid levels varied among brain regions and were not significantly affected by the diet. In control mice, the level of 22:6 n-3 was significantly higher in the frontal cortex compared to all regions. alpha-Linolenic acid deficiency decreased the level of 22:6 n-3 and was compensated by an increase in 22:5 n-6 in all regions. However, the brain regions were affected differently. After the pituitary gland, the frontal cortex, and the striatum were the most markedly affected with 40% reduction of 22:6 n-3. Supplementation with egg yolk or cerebral phospholipids in deficient mice restored a normal fatty acid composition in brain regions except for the frontal cortex. There was a regional distribution of the fatty acids in the brain and the impact of deficiency in alpha-linolenic acid was region-specific. Dietary egg yolk or cerebral phospholipids are an effective source of n-3 PUFA for the recovery of altered fatty acid composition induced by a diet deficient in n-3 PUFA.
机译：这项研究检查了饮食中的α-亚麻酸缺乏症，然后补充或不补充富含n; -3多不饱和脂肪酸（PUFA）的磷脂对11个大脑区域总磷脂脂肪酸组成的影响。交配前三周，给小鼠喂食含有亚油酸和α-亚麻酸或α-亚麻酸不足的半合成饮食。幼犬的饮食与大坝相同。在7周大的时候，一部分缺陷人群补充了来自蛋黄或猪脑磷脂的n; -3多不饱和脂肪酸（PUFA），为期2个月。饱和脂肪酸和单不饱和脂肪酸的水平在大脑区域之间变化，并且不受饮食的影响。在对照小鼠中，与所有区域相比，额叶皮层中22：6 n-3的水平明显更高。 α-亚麻酸缺乏症降低了22：6 n-3的水平，并在所有区域中以22：5 n-6的增加来补偿。但是，大脑区域受到的影响不同。垂体后叶，额叶皮层和纹状体受到的影响最明显，22：6 n-3减少了40％。在缺陷小鼠中补充蛋黄或脑磷脂可恢复除额叶皮层以外的大脑区域的正常脂肪酸组成。脑中脂肪酸的区域分布，α-亚麻酸缺乏的影响是区域特定的。饮食中的蛋黄或脑磷脂是n-3 PUFA的有效来源，可用于恢复由n-3 PUFA缺乏饮食引起的脂肪酸组成变化。

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