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首页> 外文期刊>Journal of Lipid Research >Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity.
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Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity.

机译：降低的HDL粒径是腹部肥胖的动脉粥样硬化血脂异常的另一个特征。

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Reduced plasma HDL cholesterol concentration has been associated with an increased risk of coronary heart disease. However, a low HDL cholesterol concentration is usually not observed as an isolated disorder because this condition is often accompanied by additional metabolic alterations. The objective of this study was to document the relevance of assessing HDL particle size as another feature of the atherogenic dyslipidemia found among subjects with visceral obesity and insulin resistance. For that purpose, an average HDL particle size was computed by calculating an integrated HDL particle size using nondenaturing 4-30% gradient gel electrophoresis. Potential associations between this average HDL particle size versus morphometric and metabolic features of visceral obesity were examined in a sample of 238 men. Results of this study indicated that HDL particle size was a significant correlate of several features of an atherogenic dyslipidemic profile such as increased plasma TG, decreased HDL cholesterol, high apolipoprotein B, elevated cholesterol/HDL cholesterol ratio, and small LDL particles as well as increased levels of visceral adipose tissue (AT) (0.33 < or = absolute value of r < or = 0.61, P < 0.0001). Thus, men with large HDL particles had a more favorable plasma lipoprotein-lipid profile compared with those with smaller HDL particles. Furthermore, men with large HDL particles were also characterized by reduced overall adiposity and lower levels of visceral AT as well as reduced insulinemic-glycemic responses to an oral glucose load.In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia.
机译：血浆HDL胆固醇浓度降低与冠心病风险增加有关。然而，通常不会观察到低的HDL胆固醇浓度是一种孤立的疾病，因为这种情况通常会伴随其他代谢改变。这项研究的目的是证明评估内脏肥胖和胰岛素抵抗的受试者中发现的HDL粒径是动脉粥样硬化血脂异常的另一个特征。为此，使用非变性4-30％梯度凝胶电泳通过计算积分的HDL粒径来计算平均HDL粒径。在238名男性样本中检查了平均HDL粒径与内脏肥胖的形态特征和代谢特征之间的潜在关联。这项研究的结果表明，HDL颗粒大小与动脉粥样硬化血脂异常的几个特征具有显着相关性，例如血浆TG升高，HDL胆固醇降低，载脂蛋白B高，胆固醇/ HDL胆固醇比升高，LDL小颗粒增多以及内脏脂肪组织（AT）的水平（0.33 <或= r的绝对值<或= 0.61，P <0.0001）。因此，与HDL颗粒较小的男性相比，HDL颗粒较大的男性具有更好的血浆脂蛋白-脂质分布。此外，HDL颗粒较大的男性还具有总体肥胖减少，内脏AT含量降低以及对口服葡萄糖负荷的胰岛素血糖反应降低的特点。总之，HDL颗粒较小似乎是高TG的另一个特征。 -在以高胰岛素血症为特征的内脏肥胖受试者中发现低HDL胆固醇血脂异常。

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