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首页> 外文期刊>Journal of Korean medical science >Drug fever due to piperacillin/tazobactam loaded into bone cement.
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Drug fever due to piperacillin/tazobactam loaded into bone cement.

机译：由于哌拉西林/他唑巴坦装入骨水泥中而引起的药物热。

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Although drug fever may develop after administration of the drug by various routes, it has not been reported with antibiotic-loaded bone cement. Here, a case of drug fever induced by piperacillin/tazobactam loaded into bone cement is reported. A 72-yr-old woman presented with fever that developed two weeks after insertion of bone cement loaded with antibiotics including piperacillin/tazobactam into the knee joint for infectious arthritis. The fever was associated with a skin rash and blood eosinophilia. The work-up of the fever excluded several causes. Drug provocation test demonstrated that the piperacillin/tazobactam, which had been loaded in the bone cement, was the cause of the fever. The findings of this case suggest that drug fever can be induced by any drug placed and released continuously within the body. Therefore, the evaluation for possible drug fever should include all drugs the patient has been exposed to regardless of the route of administration.
机译：尽管在通过各种途径给药后可能会出现药物热，但尚未报道使用载有抗生素的骨水泥的药物热。在此，报道了由哌拉西林/他唑巴坦加载到骨水泥中引起的药物热的病例。一名72岁的妇女发烧，在感染了关节炎的膝关节中插入了载有抗生素（包括哌拉西林/他唑巴坦）的骨水泥后两周出现发烧。发烧与皮疹和血液嗜酸性粒细胞增多有关。发烧的检查排除了几种原因。药物激发试验表明，骨水泥中已装载的哌拉西林/他唑巴坦是发烧的原因。该病例的发现表明，药物在体内连续放置和释放都会引起发烧。因此，对可能的药物发烧的评估应包括患者接触过的所有药物，而与给药途径无关。

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