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首页> 外文期刊>Journal of Korean medical science >Effect of recombinant human epidermal growth factor against cutaneous scar formation in murine full-thickness wound healing.
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Effect of recombinant human epidermal growth factor against cutaneous scar formation in murine full-thickness wound healing.

机译：重组人表皮生长因子对小鼠全层伤口愈合中皮肤瘢痕形成的影响。

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摘要

A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the formation of cutaneous scars. Twenty Crl:CD-1 (ICR) mice were used and 2 full-thickness skin wounds were made on the dorsum of each mouse. One of the wounds was treated with recombinant human EGF by local application and the other was treated with saline for control until complete healing was achieved. The EGF-treated group's wounds healed faster than the control group's. The width of the scar was smaller by 30% and the area was smaller by 26% in the EGF-treated group. Inflammatory cell numbers were significantly lower in the EGF-treated group. The expression of transforming growth factor (TGF)-beta(1) in the EGF-treated group was increased. It was observed that the amount of collagen in the EGF-treated group was larger than the control group. In the EGF-treated group, the visible external scars were less noticeable than that in the control group. These results suggest that EGF can reduce cutaneous scars by suppressing inflammatory reactions, decreasing expression of TGF-beta(1), and mediating the formation of collagen.
机译：可见的皮肤疤痕是由于炎症反应过度形成而形成的。这项研究检查了表皮生长因子（EGF）在皮肤疤痕形成中的作用。使用20只Crl：CD-1（ICR）小鼠，并在每只小鼠的背部制作2个全层皮肤伤口。伤口之一通过局部应用重组人EGF进行治疗，另一伤口通过生理盐水进行控制直至完全愈合。 EGF治疗组的伤口愈合快于对照组。在EGF治疗组中，疤痕的宽度缩小了30％，面积缩小了26％。在EGF治疗组中，炎性细胞数量明显减少。 EGF治疗组中转化生长因子（TGF）-β（1）的表达增加。观察到在EGF治疗组中胶原蛋白的量大于对照组。在EGF治疗组，可见的外部疤痕不如对照组明显。这些结果表明，EGF可以通过抑制炎症反应，减少TGF-beta（1）的表达以及介导胶原蛋白的形成来减少皮肤疤痕。

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