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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils.
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Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils.

机译：骨关节炎治疗剂氨基葡萄糖对中性粒细胞功能的抑制作用。

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摘要

Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. Neutrophils, which usually function as the primary defenders in bacterial infections, are also implicated in the destructive, inflammatory responses in arthritis. In this study, we have evaluated the effects of glucosamine on neutrophil functions using human peripheral blood neutrophils. Glucosamine (0.01-1 mM) dose-dependently suppressed the superoxide anion generation induced by formyl-Met-Leu-Phe (fMLP) or complement-opsonized zymosan and inhibited the phagocytosis of complement-opsonized zymosan or IgG-opsonized latex particles. Furthermore, glucosamine inhibited the release of granule enzyme lysozyme from phagocytosing neutrophils and suppressed neutrophil chemotaxis toward zymosan-activated serum. In addition, glucosamine inhibited fMLP-induced up-regulation of CD11b significantly, polymerization of actin, and phosphorylation of p38 mitogen-activated protein kinase (MAPK). In contrast, N-acetyl-glucosamine, an analogue of glucosamine, did not affect these neutrophil functions (superoxide generation, phagocytosis, granule enzyme release, chemotaxis, CD11b expression, actin polymerization, and p38 MAPK phosphorylation) at the concentrations examined (1-10 mM). Together these observations likely suggest that glucosamine suppresses the neutrophil functions, thereby possibly exhibiting anti-inflammatory actions in arthritis.
机译：葡萄糖胺是一种天然存在于结缔组织和软骨组织中的氨基单糖，有助于维持这些组织的强度，柔韧性和弹性。近年来，氨基葡萄糖已被广泛用于治疗人和动物模型中的骨关节炎。中性粒细胞通常在细菌感染中起主要的防御作用，但也与关节炎的破坏性炎症反应有关。在这项研究中，我们评估了使用人外周血中性粒细胞对葡糖胺对中性粒细胞功能的影响。葡萄糖胺（0.01-1 mM）剂量依赖性地抑制了甲酰-Met-Leu-Phe（fMLP）或补体调理的酵母聚糖诱导的超氧阴离子生成，并抑制了补体调理的酵母聚糖或IgG调理的乳胶颗粒的吞噬作用。此外，氨基葡萄糖抑制吞噬中性粒细胞释放颗粒酶溶菌酶，并抑制中性粒细胞对酵母聚糖活化血清的趋化性。此外，氨基葡萄糖可显着抑制fMLP诱导的CD11b上调，肌动蛋白的聚合以及p38丝裂原活化蛋白激酶（MAPK）的磷酸化。相比之下，N-乙酰氨基葡萄糖（一种氨基葡萄糖的类似物）在所检测的浓度下（1-但不影响这些中性粒细胞功能（超氧化物生成，吞噬作用，颗粒酶释放，趋化性，CD11b表达，肌动蛋白聚合和p38 MAPK磷酸化）。 10毫米）。这些观察结果可能共同表明，氨基葡萄糖会抑制嗜中性粒细胞的功能，从而可能在关节炎中表现出抗炎作用。

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