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首页> 外文期刊>Journal of Korean medical science >A novel biomarker of coronary atherosclerosis: serum DKK1 concentration correlates with coronary artery calcification and atherosclerotic plaques.
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A novel biomarker of coronary atherosclerosis: serum DKK1 concentration correlates with coronary artery calcification and atherosclerotic plaques.

机译：冠状动脉粥样硬化的新型生物标志物：血清DKK1浓度与冠状动脉钙化和动脉粥样硬化斑块相关。

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摘要

DKK1 modulates Wnt signaling, which is involved in the atherosclerosis. However, no data exist regarding the usefulness of measuring serum DKK1 concentration in predicting coronary atherosclerosis. A total of 270 consecutive patients (62.8 +/- 11.2 yr; 70% male) were included. A contrast-enhanced 64-slice coronary MDCT was performed to identify the presence of atherosclerotic plaques. Agatston calcium scores (CS) were calculated to quantify the coronary artery calcification (CAC). DKK1 concentrations were measured by enzyme-linked immunosorbent assay. For each subsequent DKK1 quartile, there was a significant increase in CAC (P = 0.004) and the number of segments with coronary atherosclerosis (P < 0.001). In addition, DKK1 concentration was significantly higher in patients with atherosclerotic plaques, regardless of plaque composition (P = 0.01). Multivariate analysis identified DKK1 as an independent risk factor for the presence of coronary atherosclerotic plaque. The adjusted odds ratio for coronary atherosclerotic plaque was 4.88 (95% CI, 1.67 to 14.25) for highest versus lowest quartile of the DKK1 levels. Furthermore, patients with DKK1 concentrations >/= 68.6 pg/mL demonstrated coronary atherosclerotic plaques even when they had low CS. Serum DKK1 concentrations correlate with the coronary atherosclerosis and play an independent role in predicting the presence of coronary atherosclerosis.
机译：DKK1调节Wnt信号传导，这与动脉粥样硬化有关。但是，目前尚无有关测量血清DKK1浓度在预测冠状动脉粥样硬化中的有用性的数据。总共包括270位连续患者（62.8 +/- 11.2年;男性占70％）。进行了增强对比的64层冠状动脉MDCT，以识别动脉粥样硬化斑块的存在。计算阿格斯顿钙评分（CS）以量化冠状动脉钙化（CAC）。通过酶联免疫吸附测定法测量DKK1浓度。对于随后的每个DKK1四分位数，CAC和冠状动脉粥样硬化的节段数均显着增加（P = 0.004）（P <0.001）。此外，无论斑块成分如何，动脉粥样硬化斑块患者的DKK1浓度均显着较高（P = 0.01）。多变量分析确定DKK1是冠状动脉粥样硬化斑块存在的独立危险因素。对于DKK1水平的最高四分位数与最低四分位数，冠状动脉粥样硬化斑块的调整后优势比为4.88（95％CI，1.67至14.25）。此外，DKK1浓度> / = 68.6 pg / mL的患者即使CS较低，也表现出冠状动脉粥样硬化斑块。血清DKK1浓度与冠状动脉粥样硬化相关，并在预测冠状动脉粥样硬化的存在中起独立作用。

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