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首页> 外文期刊>Journal of Korean medical science >Association of polymorphism in microRNA 604 with susceptibility to persistent hepatitis B virus infection and development of hepatocellular carcinoma.
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Association of polymorphism in microRNA 604 with susceptibility to persistent hepatitis B virus infection and development of hepatocellular carcinoma.

机译：microRNA 604中的多态性与持续性乙型肝炎病毒感染和肝细胞癌发展的关系。

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摘要

MicroRNA polymorphisms may be associated with carcinogenesis or immunopathogenesis of infection. We evaluated whether the mircoRNA-604 (miR-604) polymorphism can affect the persistence of hepatitis B virus (HBV) infection, and the development to hepatocellular carcinoma (HCC) in patients with chronic HBV infection. A total of 1,439 subjects, who have either past or present HBV infection, were enrolled and divided into four groups (spontaneous recovery, chronic HBV carrier without cirrhosis, liver cirrhosis and HCC). We genotyped the precursor miR-604 genome region polymorphism. The CC genotype of miR-604 rs2368392 was most frequently observed and T allele frequency was 0.326 in all study subjects. The HBV persistence after infection was higher in those subjects with miR-604 T allele (P=0.05 in a co-dominant and dominant model), which implied that the patients with miR-604 T allele may have a higher risk for HBV chronicity. In contrast, there was a higher rate of the miR-604 T allele in the chronic carrier without HCC patients, compared to those of the HCC patients (P=0.03 in a co-dominant model, P=0.02 in a recessive model). The T allele at miR-604 rs2368392 may be a risk allele for the chronicity of HBV infection, but may be a protective allele for the progression to HCC in chronic HBV carriers.
机译：MicroRNA多态性可能与感染的癌变或免疫发病机制有关。我们评估了mircoRNA-604（miR-604）多态性是否会影响乙型肝炎病毒（HBV）感染的持久性以及慢性HBV感染患者发展为肝细胞癌（HCC）的能力。共有1439名既往或曾经感染过HBV的受试者入选，分为四组（自发恢复，无肝硬化的慢性HBV携带者，肝硬化和HCC）。我们对前体miR-604基因组区域多态性进行基因分型。在所有研究对象中，miR-604 rs2368392的CC基因型最常见，T等位基因频率为0.326。患有miR-604 T等位基因的受试者感染后HBV持久性较高（在共显性和显性模型中P = 0.05），这表明具有miR-604 T等位基因的患者可能具有较高的HBV慢性病风险。相反，与HCC患者相比，无HCC患者的慢性携带者中miR-604 T等位基因的发生率更高（共显性模型中P = 0.03，隐性模型中P = 0.02）。 miR-604 rs2368392处的T等位基因可能是HBV感染慢性的危险等位基因，但可能是慢性HBV携带者发展为HCC的保护性等位基因。

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