Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.

Ricchetti GA; Williams LM; Foxwell BM

首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.

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Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.

机译：IL-10诱导的血红素加氧酶1表达需要STAT-3和磷酸肌醇3激酶，并被脂多糖抑制。

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Heme-oxygenase 1 (HO-1) is a stress-response protein with anti-inflammatory activity. This study has examined the regulation of HO-1 expression by the anti-inflammatory factor, interleukin (IL)-10 and whether HO-1 could account for the function of the cytokine. IL-10-induced expression of HO-1 required the activation of signal transducer and activator of transcription (STAT)-3 but not p38 mitogen-activated protein kinase. However, expression of HO-1 also required the activation of the phosphatidylinositol-3 kinase pathway, a signaling mechanism not required for the anti-inflammatory activity of IL-10. Moreover, induction of HO-1 expression was not restricted to IL-10, as IL-6, a cytokine known to activate STAT-3, could also induce the protein. In human macrophages, lipopolysaccharide inhibited HO-1 expression induced by IL-10. Also, inhibition of HO-1 activity by the specific inhibitor zinc-II-protoporphyrin-IX had no effect on the anti-inflammatory function of IL-10. In summary, although IL-10 does regulate HO-1 expression, it does not appear to play a significant role in the anti-inflammatory activity of the cytokine.

机译：血红素加氧酶1（HO-1）是一种具有抗炎活性的应激反应蛋白。这项研究检查了抗炎因子白介素（IL）-10对HO-1表达的调节作用，以及HO-1是否可以解释细胞因子的功能。 IL-10诱导的HO-1表达需要激活信号转导子和转录激活子（STAT）-3，但不需要p38丝裂原激活的蛋白激酶。但是，HO-1的表达还需要激活磷脂酰肌醇3激酶途径，这是IL-10抗炎活性所不需要的信号传导机制。此外，HO-1表达的诱导不仅限于IL-10，因为IL-6（一种已知可激活STAT-3的细胞因子）也可以诱导该蛋白。在人类巨噬细胞中，脂多糖抑制IL-10诱导的HO-1表达。同样，特异性抑制剂锌-II-原卟啉-IX对HO-1活性的抑制对IL-10的抗炎功能没有影响。总之，尽管IL-10确实调节HO-1的表达，但它似乎在细胞因子的抗炎活性中没有发挥重要作用。

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2004年第3期|共8页
作者
Ricchetti GA; Williams LM; Foxwell BM;
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正文语种 eng
中图分类基础医学;
关键词
1-Phosphatidylinositol 3-Kinase; Anti-Inflammatory Agents; DNA-Binding Proteins; 1-磷脂酰肌醇3-激酶; 消炎药; DNA结合蛋白质类; 白细胞介素10; 巨噬细胞; 反式作用因子;

机译：1-Phosphatidylinositol 3-Kinase;Anti-Inflammatory Agents;DNA-Binding Proteins;1-磷脂酰肌醇3-激酶;消炎药;DNA结合蛋白质类;白细胞介素10;巨噬细胞;反式作用因子;

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1. Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide. [J] . Ricchetti GA, Williams LM, Foxwell BM Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2004,第3期

机译：IL-10诱导的血红素加氧酶1表达需要STAT-3和磷酸肌醇3激酶，并被脂多糖抑制。
2. Expression of placenta growth factor, soluble fms-like tyrosine kinase-1, metal-responsive transcription factor-1, heme oxygenase 1 and hypoxia inducible factor-1 alpha mRNAs in pre-eclampsia placenta and the effect of pre-eclampsia sera on their expression of choriocarcinoma cells [J] . Maebayashi (Asanuma) Aki, Yamamoto Tatsuo, Azuma Hiromitu, The journal of obstetrics and gynaecology research . 2014,第10期

机译：子痫前期胎盘中胎盘生长因子，可溶性fms样酪氨酸激酶-1，金属反应性转录因子-1，血红素加氧酶1和低氧诱导因子-1αmRNA的表达及子痫前期血清对其表达的影响绒癌细胞
3. Mycoplasma fermentans MALP-2 Induces Heme Oxygenase-1 Expression via Mitogen-Activated Protein Kinases and Nrf2 Pathways To Modulate Cyclooxygenase 2 Expression in Human Monocytes [J] . Xiaohua Ma, Xiaoxing You, Yanhua Zeng, Clinical and vaccine immunology: CVI . 2013,第6期

机译：发酵支原体MALP-2通过丝裂素激活的蛋白激酶和Nrf2途径来调节人类单核细胞中环氧合酶2表达诱导血红素加氧酶-1的表达。
4. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats [C] . Shuyu Zhang, Jinchang Wu, Chuanjun Song, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：腺病毒介导的血红素加氧酶-1（HO-1）过表达改善辐射诱发的皮肤损伤
5. Potassium ion-induced smooth muscle calcium sensitization requires RhoA kinase (ROK) translocation to caveolae which is inhibited in non-neuronal cell memory. [D] . Urban, Nicole Hairrell. 2003

机译：钾离子诱导的平滑肌钙敏化需要RhoA激酶（ROK）易位至小窝，这在非神经元细胞记忆中受到抑制。
6. Mycoplasma fermentans MALP-2 Induces Heme Oxygenase-1 Expression via Mitogen-Activated Protein Kinases and Nrf2 Pathways To Modulate Cyclooxygenase 2 Expression in Human Monocytes [O] . Xiaohua Ma, Xiaoxing You, Yanhua Zeng, 2013

机译：发酵支原体MALP-2通过丝裂素激活的蛋白激酶和Nrf2途径来调节人类单核细胞中环氧合酶2表达诱导血红素加氧酶-1的表达。
7. Mycoplasma fermentans MALP-2 Induces Heme Oxygenase-1 Expression via Mitogen-Activated Protein Kinases and Nrf2 Pathways To Modulate Cyclooxygenase 2 Expression in Human Monocytes [O] . Xiaohua Ma, Xiaoxing You, Yanhua Zeng, 2013

机译：MACOPLASMA发酵血清MALP-2通过丝裂原激活的蛋白激酶和NRF2途径诱导血红素氧酶-1表达，以调节人单核细胞中的环氧化酶2表达

Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.

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