...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Challenges for modeling and interpreting the complex biology of severe injury and inflammation.
【24h】

Challenges for modeling and interpreting the complex biology of severe injury and inflammation.

机译：建模和解释严重伤害和炎症的复杂生物学面临的挑战。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human injury is associated with inflammatory responses that are modulated by the acute and chronic activity of endogenous factors and exogenous interventions. A characteristic feature of chronic, severe inflammatory states is the diminished signal output variability of many organ systems, including innate immune responsiveness and endogenous neural and endocrine-mediated functions. The attenuation of signal/response variability and integration of feedback capacity may contribute to systemic and tissue-specific deterioration of function. Some well-intentioned therapies directed toward support of systemic and tissue functions may actually promote the loss of system(s) adaptability and contribute to adverse outcomes in severely stressed patients. In vivo and in silico models of stress, injury, and infection have yet to fully define the influences of ongoing stressful stimulae as well as genetic variation and epigenetic factors in the context of an evolving inflammatory state. Experimental and human modelsincorporating variable, antecedent stress(es) and altered neuroendocrine rhythms might approximate the altered adaptability in immune and organ function responses. Such models may also provide insights into the salient mechanisms of risk and outcome more precisely than do the constrained study conditions of current animal or human models of systemic inflammation.
机译：人身伤害与炎症反应有关，炎症反应受内源性因素的急性和慢性活动以及外源性干预的调节。慢性，严重炎症状态的特征是许多器官系统的信号输出变异性降低，包括先天免疫应答以及内源性神经和内分泌介导的功能。信号/响应变异性的减弱和反馈能力的整合可能会导致系统性和组织特异性功能下降。某些针对支持全身和组织功能的良好治疗方法实际上可能会促进系统适应性的丧失，并导致严重压力患者的不良结局。压力，损伤和感染的体内和计算机模拟模型尚未完全定义持续的压力刺激以及正在演变的炎症状态下的遗传变异和表观遗传因素的影响。结合变量，前期应激和神经内分泌节律改变的实验模型和人体模型，可能近似反映了免疫和器官功能反应的适应性改变。与当前系统性炎症的动物或人类模型的受限研究条件相比，此类模型还可以更准确地洞察风险和结果的显着机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号