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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >IL-10 expression profiling in human monocytes.
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IL-10 expression profiling in human monocytes.

机译：人单核细胞中的IL-10表达谱。

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摘要

Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression requires the induction of an intermediate gene, we have used gene-chip technology to identify IL-10-inducible genes in human monocytes. We have been able to identify a total of 19 genes that are up-regulated in response to IL-10. Three of these genes had been identified previously: IL-1ra, suppressors of cytokine signaling-3, and CD163; however, the other 16 represent newly identified IL-10-responsive genes. Further analysis of the regulation of eight of these genes showed a remarkable specificity to regulation by lipopolysaccharides (LPS) and IL-10, but not by other anti-inflammatory mediators such as IL-4 and transforming growth factor-beta, suggesting that two diverse stimuli such as IL-10 and LPS may engage common signaling mechanisms.
机译：白介素-10（IL-10）是一种有效的抗炎细胞因子，具有多种免疫调节作用，包括抑制促炎细胞因子的产生。 IL-10发挥这些作用的机制仍然很大程度上未知。有证据表明，IL-10介导的细胞因子抑制作用需要诱导中间基因，因此我们使用基因芯片技术来鉴定人单核细胞中IL-10诱导型基因。我们已经能够鉴定出总共19个对IL-10上调的基因。这些基因中的三个先前已被鉴定出：IL-1ra，细胞因子信号传导3的抑制子和CD163。然而，其他16个代表新近鉴定的IL-10应答基因。对这8个基因的调控的进一步分析表明，它们对脂多糖（LPS）和IL-10的调控具有显着的特异性，但对其他抗炎介质（如IL-4和转化生长因子-β）的调控却不明显，这表明两种IL-10和LPS等刺激可能会参与常见的信号传导机制。

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