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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1.
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The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1.

机译：趋化因子Trp-Lys-Tyr-Met-Val-D-Met通过甲酰肽受体及其同系物之一，如甲酰肽受体1激活嗜酸性粒细胞。

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摘要

Whereas prokaryotes use L- and D-isomers of amino acids in their protein synthesis, eukaryotic proteins as a rule incorporate only L-isomers. Hence, D-isomers may constitute danger signals to the innate immune system. A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), has been shown to be a stronger activator of neutrophils than f-Met-Leu-Phe. The aim of this study was to compare the responsiveness of eosinophils to WKYMVm with that of neutrophils. The peptide was found to induce chemotaxis and respiratory burst in eosinophils. However, it did not mobilize granule constituents, as evidenced by a lack of eosinophil cationic protein, eosinophil peroxidase, and interleukin-5 in the supernatants of stimulated eosinophils. In contrast, WKYMVm caused the release of complement receptor 3 from secretory vesicles in neutrophils. Different members of the formyl peptide receptor family were preferentially engaged by the peptide in the two classes of granulocytes: the formyl peptide receptor itself in eosinophils and formyl peptide receptor-like 1 in neutrophils.
机译：原核生物在蛋白质合成中使用氨基酸的L-和D-异构体，而真核蛋白质通常仅掺入L-异构体。因此，D-异构体可能构成先天免疫系统的危险信号。一种含D-甲硫氨酸的肽Trp-Lys-Tyr-Met-Val-D-Met-NH（2）（WKYMVm），已被证明是比f-Met-Leu-Phe更强的嗜中性粒细胞活化剂。这项研究的目的是比较嗜酸性粒细胞对WKYMVm和嗜中性粒细胞的反应。发现该肽在嗜酸性粒细胞中诱导趋化性和呼吸爆发。但是，它不能动员颗粒成分，这在刺激的嗜酸性粒细胞的上清液中缺乏嗜酸性粒细胞阳离子蛋白，嗜酸性粒细胞过氧化物酶和白介素5的存在就是证明。相反，WKYMVm引起中性粒细胞分泌小泡中补体受体3的释放。肽优先参与两种粒细胞中的甲酰肽受体家族的不同成员：嗜酸性粒细胞中的甲酰肽受体本身和嗜中性粒细胞中的甲酰肽受体样1。

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