Cyclic peptide as reference system for b ion structural analysis in the gas phase

Chen X.; Tirado M.; Steill J.D.; Oomens J.; Polfer N.C.

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Cyclic peptide as reference system for b ion structural analysis in the gas phase

机译：环肽作为气相b离子结构分析的参考系统

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Infrared multiple photon dissociation spectroscopy and hydrogen/deuterium exchange methods are used to confirm the macrocylic structure of a b_6 peptide fragment by direct comparison with a synthetically made cyclic peptide. The acetylation of the peptide N-terminus results in the inhibition of the macrocyclic formation, supporting the "head-to-tail" cyclization mechanism. Differences in hydrogen/deuterium exchange rates for macrocyclic and oxazalone structure peptide fragments are interpreted to be a result of the complex interplay of multiple basic sites in the peptide fragment, supporting the relay mechanism for deuterium exchange with CH_3OD.

机译：红外多光子解离光谱法和氢/氘交换方法被用于通过与合成环状肽直接比较来确认b_6肽片段的大环结构。肽N端的乙酰化导致大环形成的抑制，支持“头到尾”环化机制。大环和奥沙酮结构肽片段的氢/氘交换速率差异被认为是肽片段中多个碱性位点复杂相互作用的结果，支持了CH_3OD氘交换的中继机制。

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《Journal of mass spectrometry: JMS》 |2011年第10期|共5页
作者
Chen X.; Tirado M.; Steill J.D.; Oomens J.; Polfer N.C.;
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正文语种 eng
中图分类分析化学;
关键词
collision-induced dissociation; cyclization; hydrogen/deuterium exchange; infrared multiple photon dissociation spectroscopy; macrocycle; peptide fragmentation mechanism;

机译：碰撞诱导解离;环化;氢/氘交换;红外多光子解离光谱;大环;肽片段化机理;

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1. Cyclic peptide as reference system for b ion structural analysis in the gas phase [J] . Chen X., Tirado M., Steill J.D., Journal of mass spectrometry: JMS . 2011,第10期

机译：环肽作为气相b离子结构分析的参考系统
2. Cyclic Peptides with a Diversely Substituted Guanidine Bridge: Solid-Phase Synthesis and Structural Analysis [J] . Dr. Youness Touati-Jallabe, Dr. Laurent Chiche, Dr. Abdallah Hamzé, Chemistry - A European Journal . 2011,第9期

机译：具有取代的胍桥的环状肽：固相合成和结构分析
3. Cyclic peptides with a diversely substituted guanidine bridge: Solid-phase synthesis and structural analysis [J] . Touati-Jallabe Y., Chiche L., Hamzé A., Chemistry: A European journal . 2011,第9期

机译：具有不同取代的胍桥的环肽：固相合成和结构分析
4. PROBING GAS PHASE PEPTIDE STRUCTURES: INSIGHT FROM SIMULATIONS MAY CONFIRM STRUCTURAL PREFERENCES IN RADICAL INDUCED TANDEM MASS SPECTROMETRY [C] . Hisham Ben Hamidane, Yury O. Tsybin Uppsala Conference School on Electron Capture and Transfer Dissociation . 2011

机译：探测气相肽结构：仿真的洞察力可以在激进诱导的串联质谱中确认结构偏好
5. Gas phase structural studies of peptide fragment ions: Structural insights into mass spectrometry fragmentation mechanisms [D] . Gucinski, Ashley Christine 2011

机译：肽片段离子的气相结构研究：质谱碎裂机理的结构见解
6. Re-investigation of phase equilibria in the system Al–Cu and structural analysis of the high-temperature phase η1-Al1−δCu [O] . Norbert Ponweiser, Christian L. Lengauer, Klaus W. Richter -1

机译：对Al-Cu体系相平衡的再研究和高温相η1-Al1-δCu的结构分析
7. Ion mobility-mass spectrometry applied to cyclic peptide analysis: conformational preferences of gramicidin S and linear analogs in the gas phase [O] . Ruotolo Brandon T, Tate Colby C, Russell David H 2004

机译：离子淌度质谱用于环肽分析：气相色谱中短杆菌肽S和线性类似物的构象偏爱
8. I. Conformational Analysis of Cyclic Peptides. II. Multinuclear NMR Spectrometer for the Study of Biological Systems [R] . Shih, W. C. W. 1979

机译：I.环肽的构象分析。 II。用于生物系统研究的多核NmR光谱仪

Cyclic peptide as reference system for b ion structural analysis in the gas phase

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