Characterization of Schlafen-3 expression in effector and regulatory T cells.

Condamine T; Le Luduec JB; Chiffoleau

首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Characterization of Schlafen-3 expression in effector and regulatory T cells.

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Characterization of Schlafen-3 expression in effector and regulatory T cells.

机译：Schlafen-3在效应和调节性T细胞中表达的表征。

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Members of the Slfn protein family have been implicated in the regulation of cell growth, hematopoietic cell differentiation, and T cell development/differentiation in the thymus. Ten members of this family have been described in the mouse, and they have been divided into three subgroups based on the overall sequence homology and the size of the encoded proteins. We have identified Slfn3, a member of Subgroup II, as an overexpressed gene in CD4(+) CD25(+) T cells in the periphery. Interestingly, we demonstrate that upon activation and proliferation, Slfn3 mRNA is down-regulated in CD4(+) CD25(+) Tregs and up-regulated in CD4(+) CD25(-) Teffs. Moreover, TGF-beta inhibits the expression of Slfn3 in anti-CD3/CD28-activated CD4+ T cells, and the same conditions induce FoxP3 mRNA. Our results suggest that Slfn3 could have a role in T cell differentiation and activation.

机译：Slfn蛋白家族的成员与胸腺中细胞生长，造血细胞分化和T细胞发育/分化的调控有关。在小鼠中已经描述了该家族的十个成员，并且根据总体序列同源性和编码蛋白的大小将它们分为三个亚组。我们已经确定Slfn3，亚组II的成员，在外围的CD4（+）CD25（+）T细胞中过表达的基因。有趣的是，我们证明激活和增殖后，Slfn3 mRNA在CD4（+）CD25（+）Tregs中下调，在CD4（+）CD25（-）Teffs中上调。此外，TGF-β抑制了抗CD3 / CD28激活的CD4 + T细胞中Slfn3的表达，并且在相同条件下诱导FoxP3 mRNA的表达。我们的结果表明Slfn3可能在T细胞分化和激活中起作用。

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2010年第3期|共6页
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Condamine T; Le Luduec JB; Chiffoleau;
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机译：Schlafen-3在效应和调节性T细胞中表达的表征。
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7. Characterization of Schlafen-3 expression in effector and regulatory T cells [O] . Thomas Condamine, Jean-benoı̂t Le Luduec, Elise Chiffoleau 2015

机译：表征schlafen-3在效应和调节性T细胞中的表达

Characterization of Schlafen-3 expression in effector and regulatory T cells.

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