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首页> 外文期刊>Journal of mass spectrometry: JMS >A mass spectrometric method for rapidly assaying the chiral selectivities of the copper(I) complexes of C-2-symmetric ligands
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A mass spectrometric method for rapidly assaying the chiral selectivities of the copper(I) complexes of C-2-symmetric ligands

机译：快速测定C-2-对称配体的铜（I）配合物的手性选择性的质谱方法

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摘要

A gas-phase method for rapidly assaying the enantioselectivity of metal-centered catalysts is presented. It relies on gas-phase equilibrium measurements in a quadrupole ion trap mass spectrometer. A group of well-established C-2-symmetric bis-oxazoline copper(I) complexes was used to identify chiral probe reagents that are capable of profiling the quality of the asymmetric environment provided by the metal complex. The chiral probes were then applied to a wide variety of copper(I) bis-di-imine complexes. Complexes based on a BINAM backbone exhibited selectivities that were comparable to the bis-oxazolines. Taking advantage of the mass selectivity capabilities of the ion trap mass spectrometer, the method was also applied to an un-purified mix of copper(I) complexes derived from a combinatorial synthesis of bis-di-imine ligands. This approach holds promise as a rapid screening tool for potential chiral catalysts. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：提出了一种气相法快速测定以金属为中心的催化剂的对映选择性。它依赖于四极离子阱质谱仪中的气相平衡测量。一组成熟的C-2-对称双恶唑啉铜（I）络合物用于鉴定手性探针试剂，该试剂能够分析金属络合物提供的不对称环境的质量。然后将手性探针应用于多种铜（I）双二亚胺配合物。基于BINAM骨架的复合物表现出与双恶唑啉相当的选择性。利用离子阱质谱仪的质量选择性功能，该方法还应用于未纯化的由双二亚胺配体的组合合成衍生的铜（I）配合物的混合物。这种方法有望成为潜在手性催化剂的快速筛选工具。版权所有（c）2015 John Wiley＆Sons，Ltd.

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