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首页> 外文期刊>Journal of mass spectrometry: JMS >A dopant for improved sensitivity in easy ambient sonic-spray ionization mass spectrometry
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A dopant for improved sensitivity in easy ambient sonic-spray ionization mass spectrometry

机译：一种可在简易环境声波喷雾电离质谱法中提高灵敏度的掺杂剂

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摘要

Recently, 3-nitrobenzonitrile (3-NBN) has been used to improve sensitivity of sonic-spray ionization mass spectrometry. Easy ambient sonic-spray ionization (EASI) is one of the simplest, gentlest and most used spray-based desorption/ionization ambient techniques, but limited sensitivity has been commonly taken as its major drawback. Herein we investigate the use of 3-NBN as a dopant in EASI-MS for improved sensitivity. Using a few typical EASI samples as test cases, the presence of 10ppm (mu gml(-1)) of 3-NBN in the spray solvent showed two to fourfold gains in EASI-MS sensitivity as measured both by total ion current and S/N ratios, accompanied with significant reductions in chemical noise. Sensitivity for DESI using 3-NBN as a dopant also improved and dopant DESI versus dopant EASI sensitivities were compared. The use of solvent dopants seems therefore to be a promising strategy to improve sensitivity for spray-based ambient MS techniques. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：最近，3-硝基苯甲腈（3-NBN）已用于提高声喷电离质谱的灵敏度。简易的环境声波喷雾电离（EASI）是最简单，最温和且最常用的基于喷雾的解吸/电离环境技术之一，但是灵敏度有限通常被视为其主要缺点。本文中，我们研究了在EASI-MS中使用3-NBN作为掺杂剂以提高灵敏度。使用几个典型的EASI样品作为测试案例，喷雾溶剂中存在10ppm（mu gml（-1））的3-NBN时，通过总离子流和S / S测得的EASI-MS灵敏度提高了2到4倍。 N比率，伴随着化学噪音的显着降低。使用3-NBN作为掺杂剂对DESI的灵敏度也得到了改善，并且比较了掺杂剂DESI与掺杂剂EASI的灵敏度。因此，使用溶剂掺杂剂似乎是提高基于喷雾的环境MS技术灵敏度的一种有前途的策略。版权所有（c）2015 John Wiley＆Sons，Ltd.

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