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BrachyView: multiple seed position reconstruction and comparison with CT post-implant dosimetry

机译:BrachyView:多个种子位置重建,并与CT植入后剂量测定法进行比较

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摘要

BrachyViewis a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 μm diameter. BrachyView was able to resolve the seed positions within 1–2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan.
机译:BrachyView是一种新颖的体内成像系统,利用高分辨率像素化硅探测器(Timepix)和针孔准直仪进行近距离放射治疗源定位。最近的研究已经研究了用于实时术中动态剂量治疗计划的各种选择,以提高植入物的质量。在先前的概念验证研究中,显示了针孔概念的合理性,从而可以进行下一步,将多个活性种子植入PMMA体模中,以模拟更现实的临床情况。在这项研究中,使用直径为400μm的铅针孔植入了20个种子并对其成像。 BrachyView能够将种子位置解析到预期位置的1-2 mm之内,这通过与完整的临床植入后CT扫描共同注册进行了验证。

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