...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Functional Foods >A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorata
【24h】

A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorata

机译：食用和药用香樟樟中生物活性代谢物Antroquinonol生物合成调控的机理研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antroquinonol, an important bioactive metabolite from the edible mushroom Antrodia camphorata, was difficult to be synthesised by conventional submerged fermentation. The present study revealed the mechanisms related to the stimulatory effect of coenzyme Q(0), camphorwood leach liquor and soybean oil on the biosynthesis of antroquinonol. Addition of coenzyme Q(0) could up-regulate the expression of S-adenosylmethionine synthetase, affording methyl group for the biosynthesis of antroquinonol. Heat shock proteins and tricarboxylic acid cycle related proteins were found to participate in the biosynthetic pathway. Camphorwood leach liquor could provide the precursor of antroquinonol by acting as donor of quinone nucleus. Soybean oil could increase the permeability of mycelial cell membrane and the extraction efficiency for the intracellular hydrophobic antroquinonol. This study advances our understanding on how stimulatory agents can be used to regulate the biosynthesis of valuable metabolites produced from mushroom mycelia and facilitate the development of submerged fermentation for potential industrial application. (C) 2016 Elsevier Ltd. All rights reserved.
机译：Antroquinonol是一种来自食用蘑菇樟芝的重要生物活性代谢物，很难通过常规的水下发酵法合成。本研究揭示了与辅酶Q（0），樟脑浸出液和大豆油对蒽醌生物合成的刺激作用有关的机制。辅酶Q（0）的添加可以上调S-腺苷甲硫氨酸合成酶的表达，从而为甲基对苯二酚的合成提供甲基。发现热激蛋白和三羧酸循环相关蛋白参与了生物合成途径。樟木浸出液可作为醌核的供体提供抗喹诺酮的前体。豆油可以提高菌丝体细胞膜的通透性和细胞内疏水性喹啉醇的提取效率。这项研究使我们对如何使用刺激剂来调节蘑菇菌丝体产生的有价值的代谢产物的生物合成以及促进深层发酵发展用于潜在工业应用的理解有了进一步的了解。 （C）2016 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号