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首页> 外文期刊>Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association >Is biliary microlithiasis a significant cause of idiopathic recurrent acute pancreatitis? A long-term follow-up study.
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Is biliary microlithiasis a significant cause of idiopathic recurrent acute pancreatitis? A long-term follow-up study.

机译：胆道微石症病是否是特发性复发性急性胰腺炎的重要原因？一项长期的随访研究。

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摘要

BACKGROUND & AIMS: The cause of recurrent acute pancreatitis (RAP) is not known in 10%-30% of patients. The aim of the present study was to determine the cause of idiopathic RAP in a long-term follow-up study. METHODS: All consecutive patients with idiopathic RAP underwent detailed evaluations and investigations to find out the cause. The pancreatitis was considered to be idiopathic when no cause could be found after standard investigations that included serum biochemistry, transabdominal ultrasonography, and computerized tomography scan of the abdomen. The detailed work-up included repeat serum biochemistry and transabdominal ultrasonography, an endoscopic retrograde cholangiopancreatography, duodenal bile microscopy to diagnose biliary microlithiasis, and endoscopic ultrasonography. RESULTS: Seventy-five patients were studied from June 1995 to May 2003. Their mean age was 31.9 years and 80% were male. The mean number of attacks of acute pancreatitis was 4.82 (range, 2-10). The cause of RAP was attributed to biliary microlithiasis in only 10 (13%) of 75 patients. Two additional patients developed gallstones during the follow-up period. Thirty-five (47%) patients developed chronic pancreatitis during the follow-up period. Ten of these 35 patients with chronic pancreatitis had biliary microlithiasis; 8 of these 10 patients had undergone cholecystectomy/endoscopic sphincterotomy yet continued to have recurrent pancreatitis and developed chronic pancreatitis. Miscellaneous causes were found in 10 (13%) patients. No cause was found in the remaining 18 (24%) patients. CONCLUSIONS: Microlithiasis was not a significant cause of idiopathic RAP in our patients. About one half of the patients with RAP developed chronic pancreatitis during the follow-up period.
机译：背景与目的：复发性急性胰腺炎（RAP）的病因在10％-30％的患者中尚不清楚。本研究的目的是在长期随访研究中确定特发性RAP的原因。方法：所有连续的特发性RAP患者都进行了详细的评估和调查，以找出原因。在通过标准检查（包括血清生物化学，经腹超声检查和计算机断层扫描）进行标准检查后，未发现原因时，认为胰腺炎是特发性的。详细的检查工作包括重复进行血清生化检查和经腹超声检查，内镜逆行胰胆管造影，十二指肠镜检查以诊断胆道微结石症和内镜超声检查。结果：1995年6月至2003年5月对75例患者进行了研究。他们的平均年龄为31.9岁，其中80％为男性。急性胰腺炎的平均发作次数为4.82（范围2-10）。 RAP的原因是75例患者中只有10例（13％）归因于胆道微石症。在随访期间，另外两名患者出现了胆结石。三十五（47％）位患者在随访期间发生了慢性胰腺炎。在这35例慢性胰腺炎患者中，有10例患有胆道微石症。这10例患者中有8例接受了胆囊切除术/内窥镜括约肌切开术，但仍继续患有复发性胰腺炎并发展为慢性胰腺炎。在10（13％）位患者中发现了其他原因。其余18名（24％）患者未发现病因。结论：微结石不是我们患者特发性RAP的重要原因。在随访期间，约有一半的RAP患者发展为慢性胰腺炎。

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