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首页> 外文期刊>Journal of Medical Entomology >Sindbis virus-associated pathology in Aedes albopictus (Diptera : Culicidae)
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Sindbis virus-associated pathology in Aedes albopictus (Diptera : Culicidae)

机译：白纹伊蚊（双翅目：path科）中与Sindbis病毒相关的病理

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摘要

Virus dissemination and associated pathology were examined in Aedes albopictus after intrathoracic inoculation of Sindbis virus (SIN), the prototypic Alphavirus. At 10 days postinfection, virus RNA was detected in all three-body segments of the insect. Colocalization of virus antigen with structural pathology was observed in mosquito salivary glands and midgut-associated visceral muscles, representing yet another example of arbovirus-associated pathology in a mosquito host. SIN antigen and gross pathology were detected in lateral lobes, but not the medial lobe of salivary glands, whereas virus antigen, vacuolated cytoplasm, and myofilament misalignment were detected in the visceral muscles at the midgut exterior surface. Early in the midgut infection, virus antigen was localized in small foci on the organ surface that progressed to a grate work-like banding pattern that eventually cleared. Both the salivary glands and the midgut are essential to insect survival and reproduction. Additionally, these organs provide a pathway for virus transmission in nature. Although SIN infection may not shorten the mosquito life span, persistent coexistence could permit survival of both host and microbe as well as contribute to alterations in insect behavior.
机译：胸腔内接种原型Alphavirus信德比斯病毒（SIN）后，在白纹伊蚊中检查了病毒的传播和相关病理。感染后第10天，在昆虫的所有三体区段中均检测到病毒RNA。在蚊唾液腺和中肠相关的内脏肌肉中观察到病毒抗原与结构病理的共定位，代表了蚊虫宿主中虫媒病毒相关病理的另一个例子。 SIN抗原和大体病理在唾液腺的外侧叶中检出，但在唾液腺的中叶未检出，而在中肠外表面的内脏肌肉中检出了病毒抗原，空泡化细胞质和肌丝错位。在中肠感染的早期，病毒抗原位于器官表面的小病灶中，逐渐发展成炉排样的带状图案，最终被清除。唾液腺和中肠对于昆虫的生存和繁殖都是必不可少的。另外，这些器官为自然界中的病毒传播提供了途径。尽管SIN感染可能不会缩短蚊子的寿命，但持久的共存可能使宿主和微生物都能存活，并有助于改变昆虫的行为。

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