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首页> 外文期刊>Journal of Medical Entomology >Wolbachia-induced mortality as a mechanism to modulate pathogen transmission by vector arthropods
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Wolbachia-induced mortality as a mechanism to modulate pathogen transmission by vector arthropods

机译：Wolbachia诱导的死亡率是调节节肢动物传播病原体的机制

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摘要

Insecticide resistance and absence of clinical cures or vaccines for many vector-borne diseases has stimulated interest in using genetically modified arthropod vectors for disease control. Current transgenic strategies focus on vector susceptibility to pathogen infection, which is an inefficient target for pathogen transmission interference. Manipulation of vector survival is theoretically more effective, resulting in larger reductions in the expected number of human infections. A hypothetical method to manipulate vector survival is to drive mortality-inducing Wolbachia into populations. For varying patterns and degrees of induced mortality, we outline the conditions under which virulent Wolbachia introductions into vector populations are expected to succeed and quantify the resultant reduction in pathogen transmission. The most critical component to the success of this strategy is the pattern of induced mortality. For operationally feasible introductions, induced mortality must be delayed until after vector reproduction begins. If this condition is not met, introduction thresholds become exceedingly high, ranging from approximate to40% to 90% of the total adult population. Delayed induced mortality patterns can reduce introduction thresholds to approximate to15-45% of the total adult population. Reduction in cytoplasmic incompatibility with male age has negligible effects on introduction success regardless of the induced mortality pattern. Under proper circumstances, symbiont-induced manipulation of vector survival can theoretically result in up to 100% reduction in pathogen transmission, depending on Wolbachia parameters, magnitude and pattern of induced mortality, and duration of pathogen incubation in the vector. Our results indicate that a broadening of the current paradigm for genetic manipulation of vectors to parameters other than arthropod vector competence is justified and will reveal new research possibilities for vector-borne disease control.
机译：对许多媒介传播疾病的抗药性和缺乏临床治疗方法或疫苗的使用，激发了人们对使用转基因节肢动物媒介进行疾病控制的兴趣。当前的转基因策略集中于载体对病原体感染的敏感性，这是病原体传播干扰的无效目标。从理论上讲，对媒介物存活的控制更为有效，从而可以大大减少预期的人类感染数量。一种假设的操纵载体存活的方法是将诱发死亡的沃尔巴氏菌驱赶到种群中。对于诱发死亡的不同模式和程度，我们概述了将毒力Wolbachia引入载体种群的成功条件，并量化了导致病原体传播的减少。该策略成功的最关键因素是诱发死亡率的模式。对于在操作上可行的引入，必须将诱导的死亡率推迟到载体繁殖开始之后。如果不满足此条件，引进门槛将变得非常高，大约占成年人口总数的40％至90％。延迟的致死模式可以将引入阈值降低到大约成年总人口的15-45％。减少与男性年龄的细胞质不相容性对引入成功的影响可忽略不计，无论诱导的死亡率模式如何。在适当情况下，共生体诱导的载体存活控制理论上可导致病原体传播减少多达100％，这取决于Wolbachia参数，诱导的死亡率的大小和模式以及病原体在载体中孵育的持续时间。我们的结果表明，将载体的遗传操作扩展到除节肢动物载体能力以外的参数的当前范式是合理的，并且将揭示载体传播疾病控制的新研究可能性。

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