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Effect of dose on house finch infection with western equine encephalomyelitis and St. Louis encephalitis viruses

机译:剂量对雀科感染西部马脑脊髓炎和圣路易斯脑炎病毒的影响

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摘要

House finches, Carpodacus mexicanus, were experimentally infected with high and standard doses of western equine encephalomyelitis virus (WEEV) or St. Louis encephalitis virus (SLEV) to determine whether high doses would produce an elevated viremia response and a high frequency of chronic infections. Finches inoculated with approximately100,000 plaque forming units (PFU) of WEEV or SLEV produced viremia and antibody responses similar to those in finches inoculated with approximately 100 PFU of WEEV or 1000 PFU of SLEV, the approximate quantities of virus expectorated by blood-feeding Culex tarsalis Coquillett. Infected finches were held through winter and then necropsied. Only one finch inoculated with the high dose of SLEV developed a chronic infection. Our data indicated that elevated infectious doses of virus may not increase the viremia level or the frequency of chronic infection in house finches.
机译:实验性地用高剂量和标准剂量的西部马脑脊髓炎病毒(WEEV)或圣路易斯脑炎病毒(SLEV)感染了家中雀(Carpodacus mexicanus),以确定高剂量是否会产生较高的病毒血症反应和高频率的慢性感染。接种约100,000个WEEV或SLEV斑块形成单位(PFU)的雀科产生的病毒血症和抗体反应与接种约100 PFU的WEEV或1000 PFU的SLEV的雀科相似,这大约是采血库克斯(Culex)吐出的病毒量草s科奎利特。感染的雀科在整个冬天都被饲养,然后进行尸检。仅一只接种高剂量SLEV的雀科发生了慢性感染。我们的数据表明,病毒感染剂量的增加可能不会增加家禽的病毒血症水平或慢性感染的频率。

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