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首页> 外文期刊>Journal of Medical Entomology >Source of host blood affects prevalence of infection and bacterial loads of Yersinia pestis in fleas.
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Source of host blood affects prevalence of infection and bacterial loads of Yersinia pestis in fleas.

机译：宿主血液的来源会影响跳蚤中鼠疫耶尔森菌的感染率和细菌载量。

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摘要

Yersinia pestis, the etiological agent of plague, is transmitted by multiple flea species. Previous studies have reported wide variability in transmission efficiency among competent vectors. However, it is unclear to what extent such variation is explained by methodological differences among studies. To optimize an artificial feeding system where fleas are infected with controlled numbers of Y. pestis under standardized laboratory conditions that could be used to systematically compare vector efficiency, we sought to test the effect of host bloodmeal source on (1) the flea's ability to remain infected with Y. pestis and (2) bacterial loads in fleas. Here, we demonstrate that both prevalence of infection with a virulent strain of Y. pestis (CO96-3188) and bacterial loads in rock squirrel fleas (Oropsylla montana) are affected by host-associated blood factors. The generality of this observation was confirmed by repeating the study using the rat flea (Xenopsylla cheopis) and a commonly used avirulent laboratory strain of Y. pestis (A1122). Implications of the results for rate of spread of Y. pestis in naturally infected host populations are discussed.
机译：鼠疫耶尔森菌是鼠疫的病原体，通过多种跳蚤物种传播。先前的研究报道称有效载体之间的传播效率差异很大。但是，尚不清楚研究之间的方法差异在多大程度上解释了这种差异。为了优化在标准实验室条件下用可控制数量的鼠疫耶尔森氏菌感染跳蚤的人工喂养系统，以用于系统比较载体效率，我们试图测试宿主血粉来源对（1）跳蚤保留能力的影响感染了鼠疫耶尔森菌和（2）跳蚤中的细菌负荷。在这里，我们证明感染鼠疫耶尔森氏菌（CO96-3188）的流行率和松鼠跳蚤（Oropsylla montana）中的细菌负荷均受宿主相关血液因素的影响。通过使用鼠蚤（Xenopsylla cheopis）和鼠疫耶尔森菌的一种常用无毒实验室菌株（A1122）重复研究，证实了这一观察结果的普遍性。讨论了鼠疫耶尔森氏菌在自然感染宿主种群中传播速度的结果。

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