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首页> 外文期刊>Journal of Medical Entomology >Knockdown Resistance (kdr) Mutations in Indian Anopheles stephensi (Diptera: Culicidae) Populations
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Knockdown Resistance (kdr) Mutations in Indian Anopheles stephensi (Diptera: Culicidae) Populations

机译：在印度按蚊（Diptera：Culicidae）种群中的抗性（kdr）突变

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Knockdown resistance (kdr) in insects resulting from mutation(s) in the voltage-gated sodium channel (VGSC) gene is one of the mechanisms of resistance against DDT and the pyrethroid group of insecticides. Earlier, we reported the presence of two classic kdr mutations, i.e., L1014F and L1014S in Anopheles stephensi Liston, a major Indian malaria vector affecting mainly urban areas. This report presents the distribution of these alleles in different An. stephensi populations. Seven populations of An. stephensi from six states of India were screened for the presence of two alternative kdr mutations L1014F and L1014S using allele-specific polymerase chain reaction assays. We recorded the presence of both kdr mutations in northern Indian populations (Alwar and Gurgaon), with the preponderance of L1014S, whereas only L1014F was present in Raipur (central India) and Chennai (southern India). None of the kdr mutations were found in Ranchi in eastern India and in Mangaluru and Mysuru in southern India. This study provides evidence for a focal pattern of distribution of kdr alleles in India.
机译：电压门控钠通道（VGSC）基因突变导致的昆虫击倒抗性（kdr）是对DDT和拟除虫菊酯类杀虫剂的抗性机制之一。早些时候，我们报道了两个经典的kdr突变，即在按蚊斯蒂芬尼·利斯顿（Anopheles stephensi Liston）中存在L1014F和L1014S，这是主要影响城市地区的主要印度疟疾传播媒介。本报告介绍了这些等位基因在不同An中的分布。斯蒂芬斯人口。安的七个人口使用等位基因特异性聚合酶链反应分析法，从印度六个州的斯蒂芬斯市筛选了两个备选的kdr突变L1014F和L1014S。我们记录了北印度人口（Alwar和古尔冈）中两个kdr突变的存在，其中L1014S占优势，而Raipur（印度中部）和Chennai（印度南部）仅存在L1014F。在印度东部的兰契（Ranchi）和印度南部的曼加鲁（Mangaluru）和米苏鲁（Mysuru），未发现kdr突变。这项研究为印度kdr等位基因分布的局灶性模式提供了证据。

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