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首页> 外文期刊>Journal of magnetic resonance >J-ONLY-TOCSY: Efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences
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J-ONLY-TOCSY: Efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences

机译：J-ONLY-TOCSY：使用JESTER-1衍生的多脉冲序列在同核TOCSY实验中有效抑制RDC诱导的转移

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摘要

The main purpose of homonuclear Hartmann-Hahn or TOCSY experiments is the assignment of spin systems based on efficient coherence transfer via scalar couplings. In partially aligned samples, however, magnetization is also transferred via residual dipolar couplings (RDCs) and therefore through space correlations can be observed in COSY and TOCSY experiments that make the unambiguous assignment of covalently bound spins impossible. In this article, we show that the JESTER-1 multiple pulse sequence, originally designed for broadband heteronuclear isotropic Hartmann-Hahn transfer, efficiently suppresses the homonuclear dipolar coupling Hamiltonian. This suppression can be enhanced even further by variation of the supercycling scheme. The application of the resulting element in homonuclear TOCSY periods results in coherence transfer via J-couplings only. As a consequence, the assignment of scalar coupled spin systems is also possible in partially aligned samples. The bandwidth of coherence transfer for the JESTER-1-derived sequences is comparable to existing TOCSY multiple pulse sequences. Results are demonstrated in theory and experiment. (c) 2007 Elsevier Inc. All rights reserved.
机译：同核Hartmann-Hahn或TOCSY实验的主要目的是基于通过标量耦合的有效相干传递来分配自旋系统。但是，在部分对齐的样品中，磁化也会通过残留的偶极耦合（RDC）进行传递，因此，通过空间相关性，可以在COZY和TOCSY实验中观察到，这使得明确确定共价结合的自旋不可能。在本文中，我们显示了最初设计用于宽带异核各向同性Hartmann-Hahn传输的JESTER-1多脉冲序列，可以有效地抑制同核偶极耦合哈密顿量。可以通过改变超级循环方案来进一步增强这种抑制。在同核TOCSY期间应用所得元素只会导致通过J耦合进行相干传递。因此，在部分对齐的样本中也可以分配标量耦合自旋系统。 JESTER-1派生序列的相干传递带宽可与现有的TOCSY多脉冲序列相媲美。结果在理论和实验上得到证明。 （c）2007 Elsevier Inc.保留所有权利。

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