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首页> 外文期刊>Journal of medical ultrasound. >High-intensity Focused Ultrasound Ablation of Soft-tissue Tumors and Assessment of Treatment Response with Multiparametric Magnetic Resonance imaging: Preliminary Study Using Rabbit VX2 Tumor Model
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High-intensity Focused Ultrasound Ablation of Soft-tissue Tumors and Assessment of Treatment Response with Multiparametric Magnetic Resonance imaging: Preliminary Study Using Rabbit VX2 Tumor Model

机译：软组织肿瘤的高强度聚焦超声消融和多参数磁共振成像评估治疗反应：使用兔VX2肿瘤模型的初步研究

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Background: High-intensity focused ultrasound (HIFU) is an emerging technique for noninvasive ablative treatment. However, HIFU has rarely been performed for the treatment of soft-tissue tumors. Thus, we aimed to assess the feasibility and safety of performing extracorporeal HIFU for the treatment of soft-tissue tumor. The treatment response was assessed using functional magnetic resonance imaging (MRI) techniques.Materials and methods: In the rabbit VX2 intramuscular tumor model, HIFU was performed using an extracorporeal HIFU device (YDME FEP-BY02) by varying the electric power from 50 to 400 W, with the other parameters being fixed. The HIFU beam was insonated to one layer of focal spots having a depth of 8 mm. The degree of ablation was evaluated by histological examination and functional MRI techniques including dynamic contrast-enhanced MRI (DCE-MRI) and apparent diffusion coefficient (ADC) map. The presence of skin burn was also evaluated. Results: Applying HIFU with an electric power of 200 W discretely produced the ablation zone without skin burn as planned before treatment (maximal depth: 8-9 mm), which shows the suitability of using HIFU (with 200 W electric power) for the treatment of soft-tissue tumors.
机译：背景：高强度聚焦超声（HIFU）是一种用于无创消融治疗的新兴技术。但是，HIFU很少用于治疗软组织肿瘤。因此，我们旨在评估进行体外HIFU治疗软组织肿瘤的可行性和安全性。使用功能磁共振成像（MRI）技术评估治疗反应。材料和方法：在兔VX2肌内肿瘤模型中，通过使用体外HIFU设备（YDME FEP-BY02）通过将电功率从50变为400来进行HIFU W，其他参数固定。 HIFU光束被超声波照射到深度为8毫米的一层焦点上。消融程度通过组织学检查和功能性MRI技术进行评估，包括动态对比增强MRI（DCE-MRI）和表观扩散系数（ADC）图。还评估了皮肤灼伤的存在。结果：使用200瓦功率的HIFU可以按照治疗前的计划离散地产生无皮肤烧蚀的消融区（最大深度：8-9 mm），这表明使用HIFU（200瓦功率的功率）进行治疗是合适的软组织肿瘤。

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