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首页> 外文期刊>Journal of magnetic resonance imaging: JMRI >Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain.
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Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain.

机译：死后多发性硬化脑中的定量磁化转移成像。

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摘要

PURPOSE: To investigate the relationship of myelin content, axonal density, and gliosis with the fraction of macromolecular protons (fB) and T2 relaxation of the macromolecular pool (T2B) acquired using quantitative magnetization transfer (qMT) MRI in postmortem brains of subjects with multiple sclerosis (MS). MATERIALS AND METHODS: fB and T2B were acquired in unfixed postmortem brain slices of 20 subjects with MS. The myelin content, axonal count, and severity of gliosis were all quantified histologically. t-Tests and multiple regression were used for analysis. RESULTS: MR indices obtained in unfixed postmortem MS brains were consistent with in vivo values reported in the literature. A significant correlation was detected between Tr(myelin) (inversely proportional to myelin content) and 1) fB (r = -0.80, P < 0.001) and 2) axonal count (r = -0.79, P < 0.001). fB differed between 1) normal-appearing white matter (NAWM) and remyelinated WM lesions (rWMLs) (mean: fB 6.9 [SD 2] vs. 4.0 [1.8], P = 0.01), and 2) rWMLs and demyelinated WMLs (mean: 4.2 [2.2] vs. 2.5 [1.3], P = 0.016). No association was detected between T2B and any of the histological measures. CONCLUSION: fB in MS WM is dependent on myelin content and may be a tool to monitor patients with this condition.
机译：目的：探讨髓磷脂含量，轴突密度和神经胶质增生与使用定量磁化转移（qMT）MRI在多发受试者的死后大脑中获得的大分子质子分数（fB）和大分子池T2弛豫（T2B）的关系。硬化症（MS）。材料与方法：fB和T2B是在20名MS患者的未固定的死后脑切片中获得的。髓磷脂含量，轴突计数和神经胶质变性的严重程度均通过组织学定量。使用t检验和多元回归进行分析。结果：未固定的死后MS脑中获得的MR指数与文献报道的体内值一致。 Tr（髓磷脂）（与髓磷脂含量成反比）与1）fB（r = -0.80，P <0.001）和2）轴突计数（r = -0.79，P <0.001）之间检测到显着相关性。 fB在1）正常出现的白质（NAWM）和髓样WM病变（rWML）之间有所不同（平均值：fB 6.9 [SD 2]对4.0 [1.8]，P = 0.01），以及2）rWML和脱髓质WML（平均值） ：4.2 [2.2]与2.5 [1.3]，P = 0.016）。在T2B与任何组织学检测方法之间均未发现关联。结论：MS WM中的fB取决于髓磷脂含量，可能是监测这种情况患者的工具。

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