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首页> 外文期刊>Journal of magnetic resonance imaging: JMRI >Clinical utility of apparent diffusion coefficient values obtained using high b-value when diagnosing prostate cancer using 3 tesla MRI: Comparison between ultra-high b-value (2000 s/mm 2) and standard high b-value (1000 s/mm 2)
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Clinical utility of apparent diffusion coefficient values obtained using high b-value when diagnosing prostate cancer using 3 tesla MRI: Comparison between ultra-high b-value (2000 s/mm 2) and standard high b-value (1000 s/mm 2)

机译：使用3 tesla MRI诊断前列腺癌时使用高b值获得的表观扩散系数值的临床实用性：超高b值（2000 s / mm 2）和标准高b值（1000 s / mm 2）的比较

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Purpose: To determine whether the apparent diffusion coefficient (ADC) obtained using b = 2000 s/mm 2 upon 3 Tesla (T) diffusion-weighted MRI is superior to b = 1000 s/mm 2 for discriminating malignant from normal prostate tissue and predicting the aggressiveness of prostate cancer, using histopathological findings of radical prostatectomy as a reference. Materials and Methods: Eighty prostate cancer patients underwent preoperative 3T MRI including diffusion weighted imaging with b-values of 0, 1000, and 2000 s/mm 2. ADCs were measured for malignant lesions and normal sites on three sets of ADC maps calculated with monoexponential fitting between b = 0 and 1000, 0 and 2000, and 1000 and 2000, respectively. The relationship between the ADC and Gleason score was evaluated. Results: The areas under the ROC curves for b = 0,1000, b = 0,2000, and b = 1000,2000 were 0.896, 0.937, and 0.857, respectively, in the peripheral zone (PZ) and 0.877, 0.889, and 0.731, respectively, in the transition zone (TZ). The difference between b = 0,1000 and b = 0,2000 was significant in PZ (P = 0.033), but not in TZ (P = 0.84). Weak but significant negative correlations were identified between ADCs and Gleason score in both PZ and TZ cancer at b = 0,1000 and b = 0,2000 (r = -0.323 to -0.341). Conclusion: For 3T MRI, ADCs using b = 0,2000 are more accurate than b = 0,1000 for diagnosing PZ cancer, and as accurate for TZ cancer.
机译：目的：确定在3特斯拉（T）扩散加权MRI上使用b = 2000 s / mm 2所获得的表观扩散系数（ADC）是否优于b = 1000 s / mm 2来区分正常前列腺组织的恶性肿瘤和预测根治性前列腺切除术的组织病理学发现作为参考。材料和方法：80例前列腺癌患者接受了术前3T MRI扫描，包括b值分别为0、1000和2000 s / mm的弥散加权成像。2.用单指数计算的三组ADC图测量ADC的恶性病变和正常部位。分别在b = 0和1000之间，0和2000之间以及1000和2000之间进行拟合。评估了ADC与格里森评分之间的关​​系。结果：在b = 0,1000，b = 0,2000和b = 1000,2000时，ROC曲线下的区域在外围区域（PZ）分别为0.896、0.937和0.857，分别为0.877、0.889和0.857。过渡区（TZ）中分别为0.731。 b = 0,1000和b = 0,2000之间的差异在PZ（P = 0.033）中是显着的，而在TZ（P = 0.84）中则没有。在b = 0,1000和b = 0,2000（r = -0.323至-0.341）的PZ和TZ癌症中，ADC与格里森评分之间发现弱但显着的负相关。结论：对于3T MRI，使用b = 0,2000的ADC在诊断PZ癌症方面比b = 0,1000更准确，而在TZ癌症方面更准确。

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