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首页> 外文期刊>Journal of microbiology, immunology, and infection: Wei mian yu gan ran za zhi >Determination of antimicrobial susceptibility patterns and inducible clindamycin resistance in Staphylococcus aureus strains recovered from southeastern Turkey.
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Determination of antimicrobial susceptibility patterns and inducible clindamycin resistance in Staphylococcus aureus strains recovered from southeastern Turkey.

机译：从土耳其东南部回收的金黄色葡萄球菌菌株的抗菌药敏模式和可诱导的克林霉素抗性的测定。

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BACKGROUND: In this study, we determined the susceptibility patterns of Staphylococcus aureus strains to various antimicrobials and prevalence of inducible clindamycin resistance (ICR) in these isolates. METHODS: Two hundred one S aureus strains, isolated from various clinical samples, were included in the study. Antibiotic susceptibilities were studied by disc diffusion method on the basis of the guidelines by the Clinical and Laboratory Standards Institute. The disc diffusion induction test (D test) was applied to determine ICR resistance among erythromycin-resistant S aureus isolates. RESULTS: Of 201 S aureus strains, 101 (50.2%) were resistant to methicillin. All strains were susceptible to vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid. It was found that 54 (53.4%) methicillin-resistant S aureus (MRSA) strains were erythromycin resistant, and 40 (39.6%) of them showed constitutive clindamycin resistance. ICR was detected in seven (6.9%) MRSA strains. It was found that 13 (13.0%) methicillin-susceptible S aureus (MSSA) strains were erythromycin resistant. Constitutive clindamycin resistance was seen in one (1.0%) MSSA strain, and ICR was detected in 10 (10.0%) cases. CONCLUSION: There was a high rate of methicillin resistance among S aureus strains in our hospital. However, no statistically significant difference of ICR was observed between MRSA and MSSA strains (p=0.434) or between inpatients and outpatients (p=0.804). It was concluded that ICR should be routinely evaluated in each S aureus case to avoid therapy failure among patients.
机译：背景：在这项研究中，我们确定了金黄色葡萄球菌菌株对各种抗菌药的敏感性模式以及这些分离株中可诱导的克林霉素耐药性（ICR）的患病率。方法：从各种临床样品中分离出的211株金黄色葡萄球菌被纳入研究。根据临床和实验室标准协会的指南，采用圆盘扩散法研究了抗生素的敏感性。应用圆盘扩散诱导测试（D测试）确定耐红霉素的金黄色葡萄球菌分离株的ICR耐药性。结果：在201株金黄色葡萄球菌中，有101株（占50.2％）对甲氧西林耐药。所有菌株均对万古霉素，替考拉宁，奎奴普丁/达福普汀和利奈唑胺敏感。已发现54株（53.4％）耐甲氧西林金黄色葡萄球菌（MRSA）具有红霉素耐药性，其中40株（39.6％）表现出对克林霉素的天然耐药性。在七个（6.9％）MRSA菌株中检测到ICR。发现13例（13.0％）对甲氧西林敏感的金黄色葡萄球菌（MSSA）对红霉素具有抗性。一例（1.0％）MSSA菌株对克林霉素具有抗药性，而十例（10.0％）病例中检测到ICR。结论：我院金黄色葡萄球菌菌株对甲氧西林的耐药率较高。但是，在MRSA和MSSA株之间（p = 0.434）或住院病人和门诊病人之间（p = 0.804），均未观察到ICR的统计学差异。得出的结论是，应在每例金黄色葡萄球菌病例中常规评估ICR，以避免患者治疗失败。

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