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首页> 外文期刊>Journal of Medical Virology >Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China.
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Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China.

机译：在中国武汉市成年人和儿童中主要有G3和新兴G9基因型的轮状病毒的系统发育分析。

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摘要

Prevalence and phylogenetic relatedness of rotaviruses causing diarrheal diseases in children and adults were analyzed in Wuhan, China. During a period between June 2006 and February 2008, group A rotavirus was identified in 24.9% (280/1126) and 7.6% (83/1088) of specimens taken from children and adults, respectively. G3P[8] was the most frequent genotype in both children (66.3%) and adults (62.7%), followed by G1P[8] (20.3% and 26.2%, respectively). G9 was detected in specimens from six children (2.0%) and seven adults (5.6%). The VP7 genes of G3P[8] rotaviruses from children and adults showed extremely high sequence identities to each other (98.9-100%) and also to those of G3 viruses isolated in Wuhan in 2003-2004. In the phylogenetic analysis of the VP7 gene, the G3P[8] rotaviruses in Wuhan were clustered into a single lineage with some G3 viruses, which had been referred to as "the new variant G3" rotaviruses, reported recently in East Asia and Southeast Asia. Similar to G3P[8] rotaviruses, extremely high sequence identities between children and adults were observed for VP7 genes of G1 and G9 rotaviruses. The G9 viruses were clustered in the lineage of globally spreading strains, while G1 viruses were genetically close to those reported previously in China and Japan. These findings indicated the persistence of the variant G3 rotaviruses and spread of G9 rotaviruses derived from the global G9 lineage in Wuhan, and suggested that the rotaviruses were circulating among children and adults, irrelevant to the G types.
机译：在中国武汉，分析了轮状病毒引起儿童和成人腹泻病的患病率和系统发育相关性。在2006年6月至2008年2月期间，分别在24.9％（280/1126）和7.6％（83/1088）的儿童和成人标本中鉴定出A组轮状病毒。 G3P [8]是儿童（66.3％）和成人（62.7％）中最常见的基因型，其次是G1P [8]（分别为20.3％和26.2％）。在六个孩子（2.0％）和七个成人（5.6％）的标本中检测到G9。来自儿童和成人的G3P [8]轮状病毒的VP7基因彼此之间具有极高的序列同一性（98.9-100％），而且与2003-2004年武汉分离出的G3病毒也具有极高的序列同一性。在对VP7基因的系统发育分析中，武汉的G3P [8]轮状病毒与一些G3病毒聚集在一个谱系中，这些病毒被称为“新的G3变种”轮状病毒，最近在东亚和东南亚报道。 。与G3P [8]轮状病毒相似，对于G1和G9轮状病毒的VP7基因，在儿童和成人之间观察到非常高的序列同一性。 G9病毒聚集在全球传播的毒株谱系中，而G1病毒在基因上与先前在中国和日本报道的病毒接近。这些发现表明变种G3轮状病毒的持续存在和源自全球G9谱系的G9轮状病毒在武汉的传播，并表明轮状病毒在儿童和成人中传播，与G类型无关。

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